Browsing by Subject "Biology, Microbiology"
Now showing items 1-20 of 25
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A Novel Mechanism for Human Papillomavirus Mediated Tumorigenesis: Examining a Role for HPV E6 Protein in CYLD Mediated NF-kappaB Activation
(2009)Human papillomavirus (HPV) infection of mucosal epithelium by `high-risk' HPV types has a prominent role in the development of anogenital intraepithelial neoplasias and carcinomas. Human epithelial cells transformed with ... -
Biochemical Characterization of Lipid A Modification Enzymes From Rhizobium leguminosarum and Rhizobium etli
(2010)The lipid A component of lipopolysaccharide (LPS) in the nitrogen-fixing plant endosymbionts <italic>Rhizobium leguminosarum</italic> and <italic>Rhizobium etli</italic> is strikingly different when compared to that of enteric ... -
Bistability, Synthetic Biology, and Antibiotic Treatment
(2010)Bistable switches are commonly observed in the regulation of critical processes such as cell cycles and differentiation. The switches possess two fundamental properties: memory and bimodality. Once switched ON, the switches ... -
Cellular Trafficking and Activation within Lymph Nodes: Contributions to Immunity and Pathogenic or Therapeutic Implications
(2010)Lymph nodes are organs of efficiency. Once activated, they essentially function to optimize and accelerate the production of the adaptive immune response, which has the potential to determine survival of the host during ... -
Cha-Cha-Cha: Variable Adhesive Activity of the <italic>Haemophilus</Italic> Cryptic Genospecies Trimeric Autotransporter Cha
(2009)Disease caused by the Gram-negative <italic>Haemophilus</italic> cryptic genospecies begins with colonization of the maternal genital or neonatal respiratory tract. The primary goal of this work was to identify and characterize ... -
Chlamydia Subversion of Host Lipid Transport: Interactions with Cytoplasmic Lipid Droplets
(2009)The <italic>Chlamydiaceae</italic> are Gram-negative, obligate intracellular bacteria that are significant pathogens of humans and animals. Intracellularly, the bacteria reside in a membrane-bound vacuole, called the inclusion, ... -
Cryptococcus Neoformans Interactions with Surfactant Proteins: Implications for Innate Pulmonary Immunity
(2009)Concurrent with the global escalation of the AIDS pandemic, cryptococcal infections are increasing and are of significant medical importance. Although improvements in antifungal therapy have advanced the treatment ... -
EVOLUTION OF THE MATING-TYPE LOCUS AND INSIGHTS INTO SEXUAL REPRODUCTION IN THE CRYPTOCOCCUS SPECIES COMPLEX
(2010)Sexual reproduction in fungi is governed by a specialized genomic region called the mating-type locus (MAT). The ascomycetes, the largest phylum of fungi, primarily possess a bipolar mating system while the basidiomycetes, ... -
Evolutionary Implications and Genetic Basis of Peroxide Survival in Saccharomyces Cerevisiae
(2009)Hydrogen peroxide is used by animals and plants to deter the growth of microbial invaders by inflicting DNA lesions, protein oxidation and lipid membrane modifications. Pathogens protect themselves with enzymes and scavenging ... -
Fundamental Mechanisms in the Extreme UV Resistance of Adenovirus
(2009)The adenoviruses are nonenveloped double stranded DNA viruses, which cause enteric dysentary and respiratory infection. Adenovirus has become a focus of the water treatment community because of its apparent resistance to ... -
Inhibition of Nucleolar Proteins in <italic>Caenorhabditis Elegans</Italic> Confers Enhanced Resistance to <italic>Salmonella Enterica</Italic> through a P53/<Italic>cep-1</Italic>-Dependent Mechanism
(2009)The relatively simple innate immune system of <italic>Caenorhabditis elegans</italic> and the number of traits that facilitate genetic and genomic analysis using this organism have nurtured rapid advances into the understanding ... -
Interactions of the MetJ Repressor from E. Coli with DNA and SAM
(2009)Transcription regulators are proteins that bind to specific DNA sequences in order to control the expression of specific genes. Often the sequences that are bound are not identical, but contain deviations from a ... -
Microbial Impacts of Selected Pharmaceutically Active Compounds Found in Domestic Wastewater Treatment Plants
(2009)Large amounts of human pharmaceutical products are consumed worldwide. Many drugs and their metabolites, referred to as pharmaceutically active compounds (PhACs), are not fully metabolized prior to household discharge resulting ... -
Molecular Approaches to Estimating Soil Fungal Diversity and Community Shifts in Response to Land-Use Change
(2010)The Piedmont region of the southeastern United States has undergone considerable land-use change since settlement by Europeans and Africans. Forests were cleared for agriculture, followed centuries later by land abandonment. ... -
Resolving Hydractiniidae and Hydroidolina Phylogeny Using Mitochondrial Genomes
(2009)TThe proposed research will provide a set of 16 near complete mtDNA gene orders. The observed gene rearrangements will be used to investigate the phylogeny of the Sub-Class Hydroidolina and the Family Hydractiniidae. All ... -
Secretion and Lipopolysaccharide Binding of Heat-Labile Enterotoxin
(2010)Enterotoxigenic <italic>Escherichia coli</italic> (ETEC) is a leading cause of morbidity and mortality worldwide. The causative agent of traveler's diarrhea, ETEC is often associated with cholera-like disease, especially ... -
Sex in Cryptococcus: Signaling, Mating-type Locus Evolution and Gene Silencing
(2008-02-26)Fungi have a genetically controlled sex determination system, which is governed by a small, sex-specific region in the genome called the mating-type locus (MAT). In the basidiomycetous yeast Cryptococcus neoformans, the ... -
Sexual Reproduction and Signal Transduction in the Candida Species Complex
(2008-08-07)Although the majority of the population carries Candida spp as normal components of their microflora, these species are important human pathogens that have the ability to cause disease under conditions of immunosuppression ... -
The Chlamydia Trachomatis Protein Interaction Network: Insights into the Unique Composition of the Type Three Secretion System
(2008-11-19)The Gram-negative bacteria Chlamydia trachomatis is a common sexually transmitted pathogen that can cause severe sequelae including cause pelvic inflammatory disease and sterility. This obligate intracellular pathogen ... -
The Effect of Afforestation on Soil Microbes and Biogeochemistry across Multiple Scales
(2009)Afforestation, the conversion of historically treeless areas into forests, is a rapidly spreading land-use change with the potential to sequester carbon. Afforested plantations typically feature fast growing exotic tree ...
