Browsing by Subject "Biology, Neuroscience"
Now showing items 1-20 of 24
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A Study of Extracting Information from Neuronal Ensemble Activity and Sending Information to the Brain Using Microstimulation in Two Experimental Models: Bipedal Locomotion in Rhesus Macaques and Instructed Reaching Movements in Owl Monkeys
(2009)The loss of the ability to walk as the result of neurological injury or disease critically impacts the mobility and everyday lifestyle of millions. The World Heath Organization (WHO) estimates that approximately 1% of the ... -
Active Staining for In Vivo Magnetic Resonance Microscopy of the Mouse Brain
(2009)Mice have become the preferred model system for studying brain function and disease. With the powerful genetic tools available, mouse models can be created to study the underlying molecular basis of neurobiology in vivo. ... -
Adolescent Response to THC: Greater Learning Impairment and Lesser Cannabinoid CB1 Receptor Desensitization in Adolescents than Adults.
(2009)Adolescence is a behaviorally well-defined developmental period during which experimentation with illicit drugs such as marijuana is common. While the lasting effects of adolescent marijuana use have been studied in humans ... -
Alteration of Golgi Apparatus Ion Homeostasis in Cellular and Mouse Models of Angelman Syndrome
(2009)Ube3a is a HECT domain E3 ubiquitin ligase originally recognized for its role in degrading p53 in the presence of the human papilloma virus protein E6. Loss of maternal Ube3a expression causes Angelman syndrome, a severe ... -
Analysis and Design of Electrodes for Deep Brain Stimulation
(2009)Deep brain stimulation (DBS) electrodes are intended to stimulate specific areas of the brain to treat movement disorders including essential tremor, Parkinson's disease and dystonia. An important goal in the design of next ... -
Analysis of the Drosophila Sugar Receptor Genes
(2009)Gustation, also known as taste perception, is critical for the survival of most animal species. The fruit fly Drosophila melanogaster employs 68 different gustatory receptors (GRs) for the detection of sugars, bitter or ... -
Analyzing the Mechanisms of Action of Thalamic Deep Brain Stimulation: Computational and Clinical Studies
(2009)Deep brain stimulation (DBS) is an established treatment for movement disorders that has been implanted in more than 40,000 patients worldwide. Despite the successes of DBS, its mechanisms of action are not well understood. ... -
Circuitry and Genes of Larval Nociception in Drosophila Melanogaster
(2009)Pain is defined by the international association of pain as an "unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage". Most people have experienced ... -
Constrained Diffusion in the Dendritic Endoplasmic Reticulum and Consequences for Early Secretory Receptor Trafficking and Postsynaptic Function
(2009)The proper modification and trafficking of plasma membrane proteins are essential for normal neuronal function, such as dendrite morphogenesis, spine formation and synaptic plasticity. The secretory organelles including ... -
Distortions in Perceived Direction of Motion Predicted by Population Response in Visual Cortex
(2009)The visual system is thought to represent the trajectory of moving objects in the activity of large populations of cortical neurons that respond preferentially to the direction of stimulus motion. Here I employed in vivo ... -
Emotional Modulation of Cognitive Skill Learning.
(2007-12-13)In this set of studies the modulation of feedback-based cognitive skill learning was investigated by modulating a probabilistic classification learning (PCL) task to be either emotional or neutral. In the current task, based ... -
Identification of Transforming Growth Factor-beta as an Extracellular Signal Required for Axon Specification in Embryonic Brain Development
(2009)The specification of a single axon and multiple dendrites is the first observable event during neuronal morphogenesis and such structural specialization underlies neural connectivity and nervous system function. Numerous ... -
Input-Specific Metaplasticity by a Local Switch in NMDA Receptors
(2009)At excitatory synapses, NMDAR-mediated synaptic plasticity occurs in response to activity inputs by modifying synaptic strength. While comprehensive studies have been focused on the induction and expression mechanisms underlying ... -
Maternally Inherited Peptides Are Strain Specific Chemosignals That Activate a New Candidate Class of Vomeronasal Chemosensory Receptor
(2009)The chemical cues that provide an olfactory portrait of mammalian individuals are in part detected by chemosensory receptors in the vomeronasal organ (VNO). By and large, the pertinent receptor-cue combinations used for ... -
Mechanisms by Which Early Nutrition Influences Spatial Memory, Adult Neurogenesis, and Response to Hippocampal Injury
(2010)Altered dietary availability of the vital nutrient choline during early development leads to persistent changes in brain and behavior throughout adulthood. Prenatal choline supplementation during embryonic days (ED) 12-17 ... -
Mouse Pheromone Receptors: the Molecular Basis of Surface Trafficking and Ligand Selectivity
(2009)Pheromones are chemicals from conspecifics that affect innate behavior or hormonal changes. In mammals, the vomeronasal organ (VNO) is thought to play a prominent role in detecting pheromones; the vomeronasal sensory neurons ... -
Neuroethology of Social Attention in Primates
(2008-11-11)To solicit the attention or determine the intentions of another, we use our eyes. While many animals appear to use eyes as an important behavioral cue, for humans, these cues are especially critical. The power of the eyes ... -
Neuronal Correlates of Reward Contingency in the Rat Thalamocortical System
(2009)Perception arises from sensory inputs detected by peripheral organs and processed in the brain by complex neuronal circuits required for the integration of external information with internal states such as expectation and ... -
Neurophysiology and Neuropharmacology of Decisions
(2009)Negotiating the complex decisions that we encounter daily requires coordinated neu- ronal activity. The enormous variety of decisions we make, the intrinsic complexity of the situations we encounter, and the extraordinary ... -
SINGLE UNIT AND ENSEMBLE RESPONSE PROPERTIES OF THE GUSTATORY CORTEX IN THE AWAKE RAT
(2007-08-10)Most studies of gustatory coding have been performed in either anesthetized or awake, passively stimulated rats. In this dissertation the influences of behavioral state on gustatory processing in awake rats are described. ...
