Browsing by Subject "Biology, Physiology"
Now showing items 1-9 of 9
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A Discrete Monolayer Cardiac Tissue Model for Tissue Preparation Specific Modeling
(2010)Engineered monolayers created by using microabrasion and micropatterning methods have provided a simplified in vitro system to study the effects of anisotropy and fiber direction on electrical propagation. Interpreting the ... -
Bifurcations in the Echebarria-Karma Modulation Equation for Cardiac Alternans in One Dimension
(2009)While alternans in a single cardiac cell appears through a simpleperiod-doubling bifurcation, in extended tissue the exact natureof the bifurcation is unclear. In particular, the phase ofalternans can exhibit wave-like spatial ... -
Characterization and Modeling of Fluctuating Hypoxia in Breast Cancer
(2008-08-08)Tumor hypoxia is an enduring problem for traditional cancer therapies such as radiation and chemotherapy. This obstacle has traditionally been attributed to the widespread presence of chronic, diffusion-limited hypoxia ... -
Defining Ankyrin-b Syndrome: Characterization of Ankyrin-b Variants in Mice and Men and the Discovery of a Role for Ankyrin-b in Parasympathetic Control of Insulin Release
(2009)Studies in the ankyrin-B+/- mouse reveal that ankyrin-B deficiency is associated with both the benefits of enhanced cardiac contractility and the costs of arrhythmia, early senescence, reduced lifespan, and impaired glucose ... -
Ecotoxicology of Natural and Anthropogenic Extreme Environments
(2010)Reactive oxygen species (ROS) are produced endogenously in all aerobes and are induced by environmental stressors. ROS oxidize and disable essential cellular components such as DNA, proteins, and lipid membranes. Exposure ... -
High Resolution X-ray Microscopy Using Digital Subtraction Angiography for Small Animal Functional Imaging
(2008-08-04)Research using mice and rats has gained interest because they are robust test beds for clinical drug development and are used to elucidate disease etiologies. Blood vessel visualization and blood flow measurements are important ... -
Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis
(2008-04-21)Reversible acetylation has emerged as an important post-translational modification that rivals phosphorylation in regulating chromatin structure and gene expression. Acetylation of histone is associated with transcriptional ... -
The role of hypoxia-inducible factor-1 in hyperthermia-induced tumor reoxygenation and therapy resistance
(2010)Imbalance between oxygen consumption and supply often makes tumors hypoxic (Bristow and Hill 2008). Tumor hypoxia is significantly correlated with aggressive tumor growth, ineffective response to radiation and chemotherapy, ... -
The Role of Threshold Size in Insect Metamorphosis and Body Size Regulation
(2010)The initiation of metamorphosis causes the cessation of the larval growth period which determines the final body size of adult insects. Because larval growth is roughly exponential, differences in timing the initiation ...
