Browsing by Subject "Biomaterials"
Now showing items 1-13 of 13
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A Tissue-Engineered Microvascular System to Evaluate Vascular Progenitor Cells for Angiogenic Therapies
(2015)The ability of tissue engineered constructs to replace diseased or damaged organs is limited without the incorporation of a functional vascular system. To design microvasculature that recapitulates the vascular niche functions ... -
Affinity-Modulation Drug Delivery Using Thermosensitive Elastin-Like Polypeptide Block Copolymers
(2010)Antivascular targeting is a promising strategy for tumor therapy. This strategy overcomes many of the transport barriers and has shown efficacy in many preclinical models, but targeting epitopes on tumor vasculature can ... -
Design of Biomaterials toward Endogenous Skeletal Tissue Repair
(2020)Repair of skeletal tissues remains a significant challenge in patient care as there is high incidence of impaired fracture healing as well as irreversible cartilage degeneration following joint injury. To improve the repair ... -
Design of Biomaterials Towards Endogenous Bone Regeneration
(2020)Bone grafting is one of the most commonly used surgical methods to augment bone regeneration in orthopedic procedure. While using natural bones, such as autograft and allograft are considered as the gold standard techniques, ... -
Development and Characterization of Mechanically Robust, 3D-Printable Photopolymers
(2017)3D printing has seen an explosion of interest and growth in recent years, especially within the biomedical space. Prized for its efficiency, ability to produce complex geometries, and facile material processing, additive ... -
Generation of Functional Hepatocyte-Like Cells (HLCs) from Human Adipose-Derived Stem Cells (ADSCs) in 2D and 3D
(2019)Mortality and morbidity rates caused by acute liver failure (ALF), acute-on-chronic liver failure (ACLF) and chronic liver disease continue to rise because of drug induced failure or viral hepatitis, currently with 2,000 ... -
Improving Indwelling Glucose Sensor Performance: Porous, Dexamethasone-Releasing Coatings that Modulate the Foreign Body Response
(2015)Inflammation and the formation of an avascular fibrous capsule have been identified as the key factors controlling the wound healing associated failure of implantable glucose sensors. Our aim is to guide advantageous tissue ... -
Microencapsulation of Octylcyanoacrylate for Applications as a Healing Agent in a Self-healing Bone Cement
(2011)Total joint replacement surgeries are performed on thousands of patients every year, yet these implants are subject to failure following prolonged exposure to the harsh environment of the body as well as the complex loading ... -
Molecular and Macroscale Engineering of Sublingual Nanofiber Vaccines
(2020)Short peptides are poorly immunogenic when delivered sublingually – under the tongue. This challenge has prevented widespread investigation into sublingual peptide vaccines, leaving their considerable potential untapped. ... -
Multiphase, Multicomponent Systems: Divalent Ionic Surfactant Phases and Single-Particle Engineering of Protein and Polymer Glasses
(2011)This thesis presents an analysis of the material properties and phase behavior of divalent ionic surfactant salts, and protein and polymer glasses. There has been extensive interest in understanding the phase behavior of ... -
Order and Disorder in Protein Biomaterial Design
(2018)Crystalline and amorphous materials have been extensively studied for their interesting properties, but they comprise a very small portion of the total materials space. The properties of most materials are a consequence ... -
The Effects of Implant-Associated Tissue Reactions on Implantable Glucose Sensor Performance
(2014)As an increasingly prevalent chronic disease, diabetes represents one of the fastest growing health burdens to both the developed and developing world. In an effort to improve the management and treatment of diabetes, ... -
Vascularized Scaffolds for Tissue Engineering Bioartificial Livers
(2020)Liver tissue engineering has made tremendous progress over the last decades, but continues to be limited by dedifferentiation of hepatocytes and insufficient vascularization of engineered constructs.1 Functional hepatocytes ...
