Browsing by Subject "Biomechanical Phenomena"
Now showing items 1-15 of 15
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Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs.
(Elife, 2015-01-09)Existing in vitro models of human skeletal muscle cannot recapitulate the organization and function of native muscle, limiting their use in physiological and pharmacological studies. Here, we demonstrate engineering ... -
Dietary inference from upper and lower molar morphology in platyrrhine primates.
(PLoS One, 2015)The correlation between diet and dental topography is of importance to paleontologists seeking to diagnose ecological adaptations in extinct taxa. Although the subject is well represented in the literature, few studies directly ... -
Energy recovery in individuals with knee osteoarthritis.
(Osteoarthritis Cartilage, 2014-06)OBJECTIVE: Pathological gaits have been shown to limit transfer between potential (PE) and kinetic (KE) energy during walking, which can increase locomotor costs. The purpose of this study was to examine whether energy exchange ... -
Evidence for an electrostatic mechanism of force generation by the bacteriophage T4 DNA packaging motor.
(Nat Commun, 2014-06-17)How viral packaging motors generate enormous forces to translocate DNA into viral capsids remains unknown. Recent structural studies of the bacteriophage T4 packaging motor have led to a proposed mechanism wherein the gp17 ... -
Functional properties of cell-seeded three-dimensionally woven poly(epsilon-caprolactone) scaffolds for cartilage tissue engineering.
(Tissue Eng Part A, 2010-04)Articular cartilage possesses complex mechanical properties that provide healthy joints the ability to bear repeated loads and maintain smooth articulating surfaces over an entire lifetime. In this study, we utilized ... -
Hand and foot pressures in the aye-aye (Daubentonia madagascariensis) reveal novel biomechanical trade-offs required for walking on gracile digits.
(J Exp Biol, 2010-05)Arboreal animals with prehensile hands must balance the complex demands of bone strength, grasping and manipulation. An informative example of this problem is that of the aye-aye (Daubentonia madagascariensis), a rare lemuriform ... -
Hip extensor mechanics and the evolution of walking and climbing capabilities in humans, apes, and fossil hominins.
(Proceedings of the National Academy of Sciences of the United States of America, 2018-04-02)The evolutionary emergence of humans' remarkably economical walking gait remains a focus of research and debate, but experimentally validated approaches linking locomotor capability to postcranial anatomy are limited. In ... -
Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism.
(Arthritis research & therapy, 2011-08-26)Tumor necrosis factor-α (TNFα) has received significant attention as a mediator of lumbar radiculopathy, with interest in TNF antagonism to treat radiculopathy. Prior studies have demonstrated that TNF antagonists can attenuate ... -
Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis.
(Arthritis Res Ther, 2012-04-17)INTRODUCTION: Osteoarthritis (OA) results in pain and disability; however, preclinical OA models often focus on joint-level changes. Gait analysis is one method used to evaluate both preclinical OA models and OA patients. ... -
Locomotor head movements and semicircular canal morphology in primates.
(Proc Natl Acad Sci U S A, 2012-10-30)Animal locomotion causes head rotations, which are detected by the semicircular canals of the inner ear. Morphologic features of the canals influence rotational sensitivity, and so it is hypothesized that locomotion and ... -
Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4.
(Arthritis Rheum, 2010-06)OBJECTIVE: To assess the role of the glycoprotein PRG4 in joint lubrication and chondroprotection by measuring friction, stiffness, surface topography, and subsurface histology of the hip joints of Prg4(-/-) and wild-type ... -
Measurement of intracellular strain on deformable substrates with texture correlation.
(J Biomech, 2007)Mechanical stimuli are important factors that regulate cell proliferation, survival, metabolism and motility in a variety of cell types. The relationship between mechanical deformation of the extracellular matrix ... -
Mechanical defenses in leaves eaten by Costa Rican howling monkeys (Alouatta palliata).
(Am J Phys Anthropol, 2006-01)Primate species often eat foods of different physical properties. This may have implications for tooth structure and wear in those species. The purpose of this study was to examine the mechanical defenses of leaves eaten ... -
Mechanobiology of the meniscus.
(J Biomech, 2015-06-01)The meniscus plays a critical biomechanical role in the knee, providing load support, joint stability, and congruity. Importantly, growing evidence indicates that the mechanobiologic response of meniscal cells plays a critical ... -
Using ground reaction force to predict knee kinetic asymmetry following anterior cruciate ligament reconstruction.
(Scand J Med Sci Sports, 2014-12)Asymmetries in sagittal plane knee kinetics have been identified as a risk factor for anterior cruciate ligament (ACL) re-injury. Clinical tools are needed to identify the asymmetries. This study examined the relationships ...
