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Browsing by Subject "Biomedical Engineering"
Now showing items 1-20 of 30
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An in vitro model of the brain tissue reaction to chronically implanted recording electrodes reveals essential roles for serum and bFGF in glial scarring
(2009)Chronically implanted recording electrode arrays linked to prosthetics have the potential to make positive impacts on patients suffering from full or partial paralysis [1;2]. Such arrays are implanted into the patient's ... -
Analysis of the Transport Behavior of Escherichia Coli in a Novel Three-Dimensional In Vitro Tumor Model
(2010)Three-dimensional (3D) tumor models aim to reduce the need for animal models for drug and gene delivery studies. However, many models are not conducive to environmental manipulation and may not be easily adapted for <italic>in ... -
Assessment of Mechanical and Hemodynamic Vascular Properties using Radiation-Force Driven Methods
(2011)Several groups have proposed classifying atherosclerotic disease by using acoustic radiationforce (ARF) elasticity methods to estimate the mechanical and materialproperties of plaque. However, recent evidence suggests that ... -
Brain-Machine-Brain Interface
(2011)Brain-machine interfaces (BMIs) use neuronal activity to control external actuators. As such, they show great promise for restoring motor and communication abilities in persons with paralysis or debilitating neurological ... -
Cartilage Lubrication and Joint Protection by the Glycoprotein PRG4 Studied on the Microscale
(2010)Human joints are able to withstand millions of loading cycles with loads regularly more than 3 times an individual's body weight in large part due to the unique bearing properties of articular cartilage, a strong, slippery ... -
Computational Modeling of Epidural Cortical Stimulation: Design, Analysis, and Experimental Evaluation
(2011)Epidural cortical stimulation (ECS) is a developing therapy for many neurological disorders. However, the mechanisms by which ECS has its effects are unknown, and this lack of understanding has limited the development and ... -
Computer Model of Mechanisms Underlying Dynamic Electrocardiographic T-wave Changes
(2011)Sudden death from arrhythmia is a major cause of mortality in the United States. Unfortunately, no current diagnostic test can accurately predict risk for sudden arrhythmic death. Because ventricular arrhythmias often result ... -
Diffusion Tensor Imaging of Myelin Water
(2011)In recent years, the emergence of diffusion tensor imaging (DTI) has provided a unique means via water diffusional characteristics to investigate the white matter integrity in the human brain, and its impact on neuronal ... -
Electrical Coupling Between Cardiomyocytes and Unexcitable Cells: The Effect of Cardiac Fibroblasts and Genetically Engineered HEK-293 Cells on Cardiac Action Potential Shape and Propagation
(2011)Excess cardiac myofibroblasts in fibrotic heart diseases as well as cell-based therapies involving implantation of stem cells or genetically engineered somatic cells in the heart may all lead to a situation where a cardiomyocyte ... -
Electrospun Scaffolds for Cartilage Tissue Engineering: Methods to Affect Anisotropy, Material and Cellular Infiltration
(2011)The aim of this dissertation was to develop new techniques for producing electrospun scaffolds for use in the tissue engineering of articular cartilage. We developed a novel method of imparting mechanical anisotropy to ... -
Enabling Technologies for Synthetic Biology: Gene Synthesis and Error-Correction from a Microarray-Microfluidic Integrated Device
(2011)Promising applications in the design of various biological systems hold critical implications as heralded in the rising field of synthetic biology. But, to achieve these goals, the ability to synthesize in situ DNA constructs ... -
Evaluation of a Dedicated SPECT-CT Mammotomography System for Quantitative Hybrid Breast Imaging
(2010)The overall goal of this dissertation is to optimize and evaluate the performance of the single photon emission computed tomography (SPECT) subsystem of a dedicated three-dimensional (3D) dual-modality breast imaging system ... -
Exploiting Optical Contrasts for Cervical Precancer Diagnosis via Diffuse Reflectance Spectroscopy
(2010)Among women worldwide, cervical cancer is the third most common cancer with an incidence rate of 15.3 per 100,000 and a mortality rate of 7.8 per 100,000 women. This is largely attributed to the lack of infrastructure and ... -
Gene level analysis of Endothelial Progenitor Cells in Co-culture
(2011)hCB-ECs show varying morphology under co-culture conditions. They are known to form networks when co-cultured on matrices like Matrigel, collagen gels and SMCs. Optimizing the co-culture model for the formation of networks ... -
Getting your research out there: open access & more.
(Ann Biomed Eng, 2012-12) -
Improving Nonviral Gene Transfer and Cellular Reprogramming with Microfluidic Nanomanufacturing
(2014)The success of gene medicine ultimately depends on the efficient intracellular delivery and sustained expression of nucleic acid therapeutics, yet nonviral gene delivery performed with cationic polymer carriers has been ... -
Influences of interpolation error, electrode geometry, and the electrode-tissue interface on models of electric fields produced by deep brain stimulation.
(IEEE transactions on bio-medical engineering, 2014-02)Deep brain stimulation (DBS) is an established therapy for movement disorders, but the fundamental mechanisms by which DBS has its effects remain unknown. Computational models can provide insights into the mechanisms of ... -
Investigating Functional Breast Image Quality and Quantification with a Dedicated SPECT-CT System
(2011)This work investigates phantom and subject positioning as well as collecting data with a variety of angular sampling and acquisition trajectories. The overall goal of this work has been to utilize the dedicated, breast SPECT-CT ... -
Microencapsulation of Octylcyanoacrylate for Applications as a Healing Agent in a Self-healing Bone Cement
(2011)Total joint replacement surgeries are performed on thousands of patients every year, yet these implants are subject to failure following prolonged exposure to the harsh environment of the body as well as the complex loading ... -
OPTIMIZATION OF IMAGE GUIDED RADIATION THERAPY USING LIMITED ANGLE PROJECTIONS
(2009)Digital tomosynthesis (DTS) is a quasi-three-dimensional (3D) imaging technique which reconstructs images from a limited angle of cone-beam projections with shorter acquisition time, lower imaging dose, and less mechanical ...
