Browsing by Subject "Biomedical engineering"
Now showing items 1-20 of 377
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3D dynamic in vivo imaging of joint motion: application to measurement of anterior cruciate ligament function
(2019)More than 400,000 anterior cruciate ligament (ACL) injuries occur annually in the United States, 70% of which are non-contact. A severe consequence of ACL injury is the increased risk of early-onset of osteoarthritis (OA). ... -
3D Human Skeletal Muscle Model for Studying Satellite Cell Quiescence and Pompe disease
(2021)Tissue-engineered skeletal muscle presents promising opportunities for developing high-fidelity in vitro models for investigating human muscle biology in the areas of regeneration and disease. In muscle regeneration, satellite ... -
A Comprehensive Framework for Adaptive Optics Scanning Light Ophthalmoscope Image Analysis
(2019)Diagnosis, prognosis, and treatment of many ocular and neurodegenerative diseases, including achromatopsia (ACHM), require the visualization of microscopic structures in the eye. The development of adaptive optics ophthalmic ... -
A Framework for Dissecting and Applying Bacterial Antibiotic Responses
(2017)An essential property of microbial communities is the ability to survive a disturbance. This is readily observed in bacteria, which have developed the ability to survive every antibiotic treatment at an alarming rate, considering ... -
A Geometric Approach to Biomedical Time Series Analysis
(2020)Biomedical time series are non-invasive windows through which we may observe human systems. Although a vast amount of information is hidden in the medical field's growing collection of long-term, high-resolution, and multi-modal ... -
A mechanistic understanding of the postantibiotic effect and treatment strategies
(2017)Although antibiotics have proven to be one of the great achievements of modern medicine, their efficacy has dramatically decreased over the past several decades. This is due, in part, to the rapid pace of natural bacterial ... -
A Model of Lung Tumor Angiogenesis in a Biomimetic Poly(ethylene glycol)-based Hydrogel System
(2016)Tumor angiogenesis is critical to tumor growth and metastasis, yet much is unknown about the role vascular cells play in the tumor microenvironment. A major outstanding challenge associated with studying tumor angiogenesis ... -
A Novel Immunoassay Platform Enabled by Non-fouling Poly(OEGMA) Surfaces
(2014)The primary barriers to multiplexed point of care immunoassays are: (1) cost; (2) response time; and (3) sample handling. Described here is a self-contained, multiplexed immunoassay platform for point of care detection that ... -
A Novel Vascular Graft Diagnostic and Reversible Aptamers for the Purification of Therapeutic Cells
(2017)Creation of novel tools for biomedical applications is critical for the improvement of patient diagnostics and therapeutics. Two particularly important needs lie in (1) improved in vitro testing and increased performance ... -
A Point-of-Care Immunoassay for Ultra-Sensitive Detection of Ebolavirus
(2020)Laboratory enabled disease diagnosis is one of the cornerstones in patient care and greatly relies in immunological techniques to detect pathogens and quantify biomarkers related to a myriad of clinical conditions. ... -
A Point-Of-Care Immunoassay Platform for Measuring Antibody Avidity
(2021)Serological testing—detection of antibodies—plays a key role in the diagnosis, management, and surveillance of infectious diseases. Serological assays can detect both active and past infections which is essential in understanding ... -
A sublingual vaccine strategy based on tablet delivery of molecular assemblies
(2019)Vaccines have been a revolutionary intervention for infectious diseases over the past many decades. However, over 2 million people continue to die every year of vaccine-preventable causes, especially in low-resource areas. ... -
A Tissue-Engineered Blood Vessel Model for Vascular Aging
(2021)Clinical studies have identified strong correlations between aging and the development of atherosclerosis. In particular, endothelial cell senescence is implicated in age-related changes in vasoreactivity. Oxidative stress ... -
A Tissue-Engineered Microvascular System to Evaluate Vascular Progenitor Cells for Angiogenic Therapies
(2015)The ability of tissue engineered constructs to replace diseased or damaged organs is limited without the incorporation of a functional vascular system. To design microvasculature that recapitulates the vascular niche functions ... -
A “Zero-Background” Multiplexed, Point-Of-Care Testing Platform for Disease Diagnosis, Management, and Surveillance
(2022)Bioanalytical techniques such as immunoassays are ubiquitous in clinical and basic research laboratories and have transformed how we diagnose patients, monitor health, and study disease. Immunoassays typically use capture ... -
Accelerated Sepsis Diagnosis by Seamless Integration of Nucleic Acid Purification and Detection
(2014)<bold>Background</bold> The diagnosis of sepsis is challenging because the infection can be caused by more than 50 species of pathogens that might exist in the bloodstream in very low concentrations, e.g., less ... -
Achieving Dynamic Control over Cell Culture Hydrogels Using Engineered Proteins
(2020)It has been understood for some time that cells are profoundly influenced by their environment. Recently, researchers have made great strides in engineering cell culture platforms that are both physiologically mimetic and ... -
Acoustic and Magnetic Techniques for the Isolation and Analysis of Cells in Microfluidic Platforms
(2016)Cancer comprises a collection of diseases, all of which begin with abnormal tissue growth from various stimuli, including (but not limited to): heredity, genetic mutation, exposure to harmful substances, radiation as well ... -
Acoustic Radiation Force Impulse Imaging of Radiofrequency Ablation Lesions for Cardiac Ablation Procedures
(2013)This dissertation investigates the use of intraprocedure acoustic radiation force impulse (ARFI) imaging for visualization of radiofrequency ablation (RFA) lesions during cardiac transcatheter ablation (TCA) procedures. ... -
Acoustofluidic Manipulation for Diagnosis and Drug Loading
(2021)Showing increased application in biological and medical fields, acoustofluidics is a combined technology between acoustics and microfluidics. The core function of acoustofluidics is a label-free and contact-free manipulation ...
