Browsing by Subject "Blood Coagulation"

Prothrombin Complex Concentrates for Bleeding in the Perioperative Setting.

Ghadimi, Kamrouz; Levy, Jerrold H; Welsby, Ian J (Anesth Analg, 2016-05)

Prothrombin complex concentrates (PCCs) contain vitamin K-dependent clotting factors (II, VII, IX, and X) and are marketed as 3 or 4 factor-PCC formulations depending on the concentrations of factor VII. PCCs rapidly restore ...

Strong Binding of Platelet Integrin αIIbβ3 to Fibrin Clots: Potential Target to Destabilize Thrombi.

Höök, Peter; Litvinov, Rustem I; Kim, Oleg V; Xu, Shixin; Xu, Zhiliang; Bennett, Joel S; Alber, Mark S; ... (8 authors) (Scientific reports, 2017-10-11)

The formation of platelet thrombi is determined by the integrin αIIbβ3-mediated interactions of platelets with fibrinogen and fibrin. Blood clotting in vivo is catalyzed by thrombin, which simultaneously induces fibrinogen ...

Use of PER977 to reverse the anticoagulant effect of edoxaban.

Ansell, Jack E; Bakhru, Sasha H; Laulicht, Bryan E; Steiner, Solomon S; Grosso, Michael; Brown, Karen; Dishy, Victor; ... (9 authors) (N Engl J Med, 2014-11-27)