Browsing by Subject "Brachytherapy"
Now showing items 1-9 of 9
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Brachytherapy Dosimetry: Working towards in-vivo and end-to-end diametric checks in modern HDR brachytherapy
(2018)Treatment errors can occur in high dose rate (HDR) brachytherapy, but, currently, there is a lack of real-time treatment verification systems that are clinically available and thus many errors are only determined retrospectively, ... -
Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours.
(Nature biomedical engineering, 2022-10)Locally advanced pancreatic tumours are highly resistant to conventional radiochemotherapy. Here we show that such resistance can be surmounted by an injectable depot of thermally responsive elastin-like polypeptide (ELP) ... -
Chest Phantom Development for Chest X-ray Radiation Protection Surveys, Internal Beta Dosimetry of an Iodine-131 Labelled Elastin-Like Polypeptide, and I-131 Beta Detection Using a Scintillating Nanoparticle Detector
(2018)Project 1: Chest Phantom Development for Chest X-ray Radiation Protection SurveysPurpose: Develop an acrylic phantom to accurately represent an average adult’s chest for use in radiographic chest unit radiation protection ... -
Efficacy of ELP as an Intratumoral Depot for Radionuclide Therapy of PC-3 Prostate Cancer in an Orthotopic, Nude Mouse Model
(2012)Brachytherapy has emerged as one of the pre-eminent radiotherapy modalities for the treatment of prostate cancer. Current clinical methods utilize titanium encased radioactive seeds that are fixated within the prostate ... -
Multi-Material 3D Printing In Brachytherapy: Prototyping Teaching Tools
(2020)The utilization of brachytherapy practice in clinics has been declining over the years. The decline has been linked to a variety of factors including a lack of training opportunities. To improve the quality of intracavitary ... -
On the Feasibility of a Novel In-Vivo Dosimeter for Brachytherapy
(2013)Purpose: Clinical brachytherapy systems are capable of delivering very high doses with high dose gradients. It is important therefore to be able to accurately verify the doses calculated by brachytherapy treatment planning. ... -
Techniques to Improve Gynecological High-Dose-Rate Brachytherapy Treatments
(2019)The thesis has two parts. The first project relates to real time dosimetry in Gynecological (GYN) High Dose Rate (HDR) Brachytherapy Treatments and the second part investigates a new workflow for Image Guided Brachytherapy ... -
Thermally-Responsive Biopolymer Depots for the Delivery of High-Dose, β-Radionuclide Brachytherapy in the Treatment of Prostate and Pancreatic Cancer
(2018)Intratumoral radiation therapy – ‘brachytherapy’ – is a highly effective treatment for solid tumors, particularly prostate cancer. Current titanium seed implants, however, are permanent and are limited in clinical application ... -
Uncertainties in MR-to-CT Image Registration for HDR Cervical Brachytherapy
(2021)MR-based planning provides many benefits to planning of the HDR brachytherapy component of treatments for cervical cancer patients but requires the acquisition of different imaging sets that need to be registered for planning. ...
