Browsing by Subject "Breast-Cancer"
Now showing items 1-11 of 11
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A Biopsychosocial Study of the Mammography Pain Experiences of Breast Cancer Survivors
(2009)Based on a biopsychosocial model of mammography pain, the current study assessed if specific biological and psychosocial factors were associated with higher reported mammography pain in early stage breast cancer survivors. ... -
A Mechanism and Pro-migratory Function for Non-canonical TGF-beta Signaling through Smad1 and Smad5
(2008-12-10)During the course of breast cancer progression, normally dormant tumor-promoting effects of transforming growth factor-beta (TGF-beta) including migration, invasion, and metastasis are unmasked. Although this switch or ... -
Correlation Imaging for Improved Cancer Detection
(2008-11-10)We present a new x-ray imaging technique, Correlation Imaging (CI), for improved breast and lung cancer detection. In CI, multiple low-dose radiographic images are acquired along a limited angular arc. Information ... -
Development of an Integrated SPECT-CmT Dedicated Breast Imaging System Incorporating Novel Data Acquisition and Patient Bed Designs
(2010)This thesis research builds upon prior work that developed separate SPECT and CT (computed mammotomography, or breast CT) devices that were independently capable of imaging an uncompressed breast in 3D space. To further ... -
Malignancy detection performance using excised breast tumor margin spectroscopic data and an optimal decision fusion based approach
(2010)Approximately 20-70% of women with breast cancer who choose to undergo breast-conserving surgery (BCS) need to return to the operating table for re-excision [1]. Now devices utilizing optical spectroscopy are emerging as ... -
Metabolic Exogenous Contrast Agents for use in Breast Cancer Detection and Therapy Monitoring
(2010)Functional imaging gives clinicians the ability to monitor breast cancer progression and response to therapy. Modern techniques such as Positron Emission Tomography (PET) has allowed for clinicians to visualize the metabolic ... -
Multimodal Regulation of Gene Transcription by Progestins
(2009)The progesterone receptor (PR) is a member of the nuclear receptor superfamily of ligand-regulated transcription factors. The steroid hormone progesterone binds to PR and induces a conformational change that enables the ... -
Role of the Type III TGF-beta Receptor Cytoplasmic Domain in Breast Cancer Progression
(2009)Breast cancer remains among the most common cancers of the developed world. Despite advances in treatment modalities, deaths due to breast cancer are the second leading cause of cancer death among women. The transforming ... -
Role of X-Linked Inhibitor of Apoptosis Protein in Therapeutic Resistance of Inflammatory Breast Cancer Cells
(2010)Apoptotic dysregulation is a hallmark of cancer cells. The inability of cancer cells to undergo apoptosis may lead to therapeutic resistance. Inflammatory breast cancer (IBC) is a highly aggressive subtype of breast cancer ... -
The Role of the Myelin and Lymphocyte Protein (MAL) in Breast and Ovarian Cancer
(2010)MAL (myelin and lymphocyte protein), has been implicated in several malignancies including esophageal, gastric, and cervical cancers. We have demonstrated that the MAL protein is expressed in the normal breast epithelium, ... -
The Roles of Rap1 in Cancer Metastasis and Pancreatic Islet Beta Cell Function
(2009)Signaling from the G protein, Rap1 is involved in several fundamental biological processes. Yet the mechanism or even consequence of Rap1 signaling in several biologies and diseases is still unclear. Rap1 has been implicated ...
