Now showing items 1-5 of 5

    • C-reactive protein, fibrinogen, and cardiovascular disease prediction. 

      Pencina, Michael; Kaptoge, Stephen; Di Angelantonio, Emanuele; Pennells, Lisa; Wood, Angela M; White, Ian R; Gao, Pei; ... (84 authors) (The New England journal of medicine, 2012-10)
      There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events.We analyzed data from 52 prospective studies that included ...
    • Childhood bullying involvement predicts low-grade systemic inflammation into adulthood. 

      Copeland, WE; Wolke, D; Lereya, ST; Shanahan, L; Worthman, C; Costello, EJ (Proc Natl Acad Sci U S A, 2014-05-27)
      Bullying is a common childhood experience that involves repeated mistreatment to improve or maintain one's status. Victims display long-term social, psychological, and health consequences, whereas bullies display minimal ...
    • Deficiency of α-1-antitrypsin influences systemic iron homeostasis. 

      Fischer, Bernard Martin; Ghio, Andrew J; Richards, JH; Schmechel, DE; Soukup, JM; Voynow, JA (Int J Chron Obstruct Pulmon Dis, 2013)
      There is evidence that proteases and antiproteases participate in the iron homeostasis of cells and living systems. We tested the postulate that α-1 antitrypsin (A1AT) polymorphism and the consequent deficiency ...
    • Effects of an antisense oligonucleotide inhibitor of C-reactive protein synthesis on the endotoxin challenge response in healthy human male volunteers. 

      Baker, BF; Crooke, RM; Flaim, JD; Graham, MJ; Hughes, S; Noveck, Robert; Ridker, PM; ... (8 authors) (J Am Heart Assoc, 2014-07-10)
      BACKGROUND: C-reactive protein (CRP) binds to damaged cells, activates the classical complement pathway, is elevated in multiple inflammatory conditions, and provides prognostic information on risk of future atherosclerotic ...
    • Is chronic asthma associated with shorter leukocyte telomere length at midlife? 

      Belsky, Daniel W; Caspi, Avshalom; Hancox, RJ; Harrington, Hona Lee; Houts, Renate M; Moffitt, Terrie E; Poulton, R; ... (11 authors) (Am J Respir Crit Care Med, 2014-08-15)
      RATIONALE: Asthma is prospectively associated with age-related chronic diseases and mortality, suggesting the hypothesis that asthma may relate to a general, multisystem phenotype of accelerated aging. OBJECTIVES: To test ...