Now showing items 1-5 of 5

    • C-reactive protein, fibrinogen, and cardiovascular disease prediction. 

      Emerging Risk Factors Collaboration; Kaptoge, Stephen; Di Angelantonio, Emanuele; Pennells, Lisa; Wood, Angela M; White, Ian R; Gao, Pei; ... (84 authors) (The New England journal of medicine, 2012-10)
      There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events.We analyzed data from 52 prospective studies that included ...
    • Childhood bullying involvement predicts low-grade systemic inflammation into adulthood. 

      Copeland, William E; Wolke, Dieter; Lereya, Suzet Tanya; Shanahan, Lilly; Worthman, Carol; Costello, E Jane (Proc Natl Acad Sci U S A, 2014-05-27)
      Bullying is a common childhood experience that involves repeated mistreatment to improve or maintain one's status. Victims display long-term social, psychological, and health consequences, whereas bullies display minimal ...
    • Deficiency of α-1-antitrypsin influences systemic iron homeostasis. 

      Ghio, Andrew J; Soukup, Joleen M; Richards, Judy H; Fischer, Bernard M; Voynow, Judith A; Schmechel, Donald E (Int J Chron Obstruct Pulmon Dis, 2013)
      There is evidence that proteases and antiproteases participate in the iron homeostasis of cells and living systems. We tested the postulate that α-1 antitrypsin (A1AT) polymorphism and the consequent deficiency ...
    • Effects of an antisense oligonucleotide inhibitor of C-reactive protein synthesis on the endotoxin challenge response in healthy human male volunteers. 

      Noveck, Robert; Stroes, Erik SG; Flaim, JoAnn D; Baker, Brenda F; Hughes, Steve; Graham, Mark J; Crooke, Rosanne M; ... (8 authors) (J Am Heart Assoc, 2014-07-10)
      BACKGROUND: C-reactive protein (CRP) binds to damaged cells, activates the classical complement pathway, is elevated in multiple inflammatory conditions, and provides prognostic information on risk of future atherosclerotic ...
    • Is chronic asthma associated with shorter leukocyte telomere length at midlife? 

      Belsky, Daniel W; Shalev, Idan; Sears, Malcolm R; Hancox, Robert J; Lee Harrington, Hona; Houts, Renate; Moffitt, Terrie E; ... (11 authors) (Am J Respir Crit Care Med, 2014-08-15)
      RATIONALE: Asthma is prospectively associated with age-related chronic diseases and mortality, suggesting the hypothesis that asthma may relate to a general, multisystem phenotype of accelerated aging. OBJECTIVES: To test ...