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Browsing by Subject "Caenorhabditis elegans"
Now showing items 1-20 of 28
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C. elegans germline-deficient mutants respond to pathogen infection using shared and distinct mechanisms.
(PLoS One, 2010-07-26)Reproduction extracts a cost in resources that organisms are then unable to utilize to deal with a multitude of environmental stressors. In the nematode C. elegans, development of the germline shortens the lifespan of the ... -
dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest.
(PLoS Genet, 2015-12)Nutrient availability has profound influence on development. In the nematode C. elegans, nutrient availability governs post-embryonic development. L1-stage larvae remain in a state of developmental arrest after hatching ... -
Effects of chemical exposures on mitochondrial mutagenesis across species
(2022)Mitochondria are essential organelles required for all eukaryotic life on earth. Each organelle contains multiple copies of the mitochondrial genome (mtDNA) that encodes genes essential for energy production. Mutations in ... -
From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans.
(Toxicol Sci, 2016-08)Millions of people worldwide are chronically exposed to arsenic through contaminated drinking water. Despite decades of research studying the carcinogenic potential of arsenic, the mechanisms by which arsenic causes cancer ... -
High-throughput isolation and mapping of C. elegans mutants susceptible to pathogen infection.
(PLoS One, 2008-08-06)We present a novel strategy that uses high-throughput methods of isolating and mapping C. elegans mutants susceptible to pathogen infection. We show that C. elegans mutants that exhibit an enhanced pathogen accumulation ... -
Identification of late larval stage developmental checkpoints in Caenorhabditis elegans regulated by insulin/IGF and steroid hormone signaling pathways.
(PLoS Genet, 2014-06)Organisms in the wild develop with varying food availability. During periods of nutritional scarcity, development may slow or arrest until conditions improve. The ability to modulate developmental programs in response to ... -
Interactions between oxidative stress and insulin/IGF-1 signaling for starvation resistance in Caenorhabditis elegans
(2019-04-22)Reactive oxygen species (ROS) are a natural byproduct of metabolism with roles in cell signaling and homeostasis but also generate oxidative stress. Past research demonstrates that ROS are a major factor in pathological ... -
Later-life Effects of Mitochondrial DNA Damage During Development in the Whole Organism Model Caenorhabditis elegans
(2012)Early life exposure to mitochondrial toxicants, including paraquat, rotenone, and manganese, has been hypothesized to promote early onset of genetic mitochondrial disorders as well as common degenerative diseases such as ... -
Muscle contraction alters hemicentin dynamics at the B-LINK: a newly identified basement membrane adhesion system that connects tissues.
(2017-05-11)Basement membranes (BMs) are thin, dense sheets of extracellular matrix found covering most tissues in multicellular organisms. In some instances, BMs of adjacent tissues can become linked and attach tissues together. A ... -
Mutation accumulation may be a minor force in shaping life history traits.
(PLoS One, 2012)Is senescence the adaptive result of tradeoffs between younger and older ages or the nonadaptive burden of deleterious mutations that act at older ages? To shed new light on this unresolved question we combine adaptive and ... -
Nutritional control of mRNA isoform expression during developmental arrest and recovery in C. elegans.
(Genome Res, 2012-10)Nutrient availability profoundly influences gene expression. Many animal genes encode multiple transcript isoforms, yet the effect of nutrient availability on transcript isoform expression has not been studied in genome-wide ... -
Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression.
(Mol Syst Biol, 2008)Biological networks are inherently modular, yet little is known about how modules are assembled to enable coordinated and complex functions. We used RNAi and time series, whole-genome microarray analyses to systematically ... -
Pol II docking and pausing at growth and stress genes in C. elegans.
(Cell Rep, 2014-02-13)Fluctuations in nutrient availability profoundly impact gene expression. Previous work revealed postrecruitment regulation of RNA polymerase II (Pol II) during starvation and recovery in Caenorhabditis elegans, suggesting ... -
Recovery from an acute infection in C. elegans requires the GATA transcription factor ELT-2.
(PLoS Genet, 2014-10)The mechanisms involved in the recognition of microbial pathogens and activation of the immune system have been extensively studied. However, the mechanisms involved in the recovery phase of an infection are incompletely ... -
Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform.
(Neuron, 2012-11-08)MAPKKK dual leucine zipper-bearing kinases (DLKs) are regulators of synaptic development and axon regeneration. The mechanisms underlying their activation are not fully understood. Here, we show that C. elegans DLK-1 is ... -
Robo functions as an attractive cue for glial migration through SYG-1/Neph.
(eLife, 2020-11-19)As one of the most-studied receptors, Robo plays functions in many biological processes, and its functions highly depend on Slit, the ligand of Robo. Here we uncover a Slit-independent role of Robo in glial migration and ... -
Robust test method for time-course microarray experiments.
(BMC Bioinformatics, 2010-07-22)BACKGROUND: In a time-course microarray experiment, the expression level for each gene is observed across a number of time-points in order to characterize the temporal trajectories of the gene-expression profiles. For many ... -
Role of Mitochondrial Dynamics and Autophagy in Removal of Helix-Distorting Mitochondrial DNA Damage
(2012)Mitochondria are the primary energy producers of the cell and play key roles in cellular signaling, apoptosis and reactive oxygen species (ROS) production. Mitochondria are the only organelles that contain their own genome ... -
Sensitive and precise quantification of insulin-like mRNA expression in Caenorhabditis elegans.
(PLoS One, 2011-03-22)Insulin-like signaling regulates developmental arrest, stress resistance and lifespan in the nematode Caenorhabditis elegans. However, the genome encodes 40 insulin-like peptides, and the regulation and function of individual ... -
Succinylated octopamine ascarosides and a new pathway of biogenic amine metabolism in Caenorhabditis elegans.
(J Biol Chem, 2013-06-28)The ascarosides, small-molecule signals derived from combinatorial assembly of primary metabolism-derived building blocks, play a central role in Caenorhabditis elegans biology and regulate many aspects of development and ...
