Browsing by Subject "Cancer"
Now showing items 1-20 of 55
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A Cloud-Based Infrastructure for Cancer Genomics
(2020)The advent of new genomic approaches, particularly next generation sequencing (NGS) has resulted in explosive growth of biological data. As the size of biological data keeps growing at exponential rates, new methods for ... -
A Controlled Breathing Intervention for Women Undergoing MRI-Guided Breast Biopsy: A Randomized Controlled Trial
(2020)Controlled breathing techniques are widely used to help people manage pain, and there is growing interest in using these approaches during painful outpatient medical procedures. The outpatient MRI-guided breast biopsy is ... -
A Pattern Fusion Algorithm to Determine the Effectiveness of Predictions of Respiratory Surrogate Motion Multiple-Steps Ahead of Real Time
(2015)Purpose: Ensuring that tumor motion is within the radiation field for high-dose and high-precision radiosurgery in areas greatly influenced by respiratory motion. Therefore tracking the target or gating the radiation beam ... -
A Toolbox for Observing and Modulating the Gut-Brain Axis
(2022)An estimated 10% of people worldwide have an enteric nervous system (ENS) related illness including irritable bowel syndrome (IBS), diabetes, colorectal cancer, fecal incontinence, and chronic constipation or diarrhea. Current ... -
Achieving Cell-Specific Delivery of Multiple Oligonucleotide Therapeutics with Aptamer Chimeras
(2012)Current standard cancer treatments such as chemotherapeutics, and radiation therapy are nearly as likely to kill the patient as cure the cancer. Therapies that have such a narrow window of efficacy are necessary for the ... -
Affinity-Modulation Drug Delivery Using Thermosensitive Elastin-Like Polypeptide Block Copolymers
(2010)Antivascular targeting is a promising strategy for tumor therapy. This strategy overcomes many of the transport barriers and has shown efficacy in many preclinical models, but targeting epitopes on tumor vasculature can ... -
Bone Morphogenetic Proteins Signal through Smad1/5/8 to induce MET, Smad2 to Specify the Dorsoventral Axis and Smad3 to Facilitate Invasion.
(2013)The bone morphogenetic protein (BMP) signaling pathways have important roles in embryonic development and homeostasis. BMPs have been shown to pattern the dorsoventral axis in zebrafish (<italic>Danio rerio</italic>) early ... -
CAR T-cell Immunotherapy for Brain Tumors
(2017)Glioblastoma (GBM) is the most common and deadly primary malignant brain tumor. Despite an aggressive multimodal standard of care, prognoses and patient quality of life remain exceptionally poor, due in part to the non-specific ... -
Cell and extracellular matrix growth theory and its implications for tumorigenesis.
(Bio Systems, 2021-03)Cells associated with an abnormal (cancerous) growth exchange flows, morph freely and grow hand-in-glove with their immediate environment, the extracellular matrix (ECM). The cell structure experiences two mass flows in ... -
Chemical Biology Approaches to Interrogate Heat Shock Transcription Factor 1 Regulation in Cancer
(2020)Heat Shock transcription Factor 1 (HSF1) has long been recognized as the master regulator and signal integrator in the eukaryotic proteotoxic stress response. Revealed by recent discoveries in cancer, the functions of HSF1 ... -
Chemotherapeutic drug screening in 3D-Bioengineered human myobundles provides insight into taxane-induced myotoxicities.
(iScience, 2022-10)Two prominent frontline breast cancer (BC) chemotherapies commonly used in combination, doxorubicin (DOX) and docetaxel (TAX), are associated with long-lasting cardiometabolic and musculoskeletal side effects. Whereas DOX ... -
Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis.
(The Journal of clinical investigation, 2019-01)Recurrent broad-scale heterozygous deletions are frequently observed in human cancer. Here we tested the hypothesis that compound haploinsufficiency of neighboring genes at chromosome 8p promotes tumorigenesis. By targeting ... -
Defining and Targeting Epigenetic Rewiring During Tumor Progression
(2019)Tumor recurrence following initial treatment is the leading cause of death among breast cancer patients. Epigenetic mechanisms are critical for regulation of gene expression and to facilitate appropriate responses ... -
Designing a Low-Cost Cancer Therapeutic with Ethanol Ablation and Immunomodulation
(2021)Breast cancer outcomes globally are dependent on access to advanced operating room technology and radiation therapy facilities. In low-income countries, 90% of patients cannot access either radiation or surgery due to a ... -
Development and Optimization of Four-dimensional Magnetic Resonance Imaging (4D-MRI) for Radiation Therapy
(2016)A tenet of modern radiotherapy (RT) is to identify the treatment target accurately, following which the high-dose treatment volume may be expanded into the surrounding tissues in order to create the clinical and planning ... -
Development of Clinically Translatable Technologies for Optical Image-Guided Breast Tumor Removal Surgery
(2014)The rate of occurrence and number of deaths associated with cancer continues to climb each year despite the continual efforts to battle the disease. When given a cancer diagnosis, it is particularly demoralizing and devastating ... -
Dissecting Mechanisms of Tumor Response and Resistance to Radiation and Immunotherapy
(2020)Over half of all cancer patients receive radiation therapy, and it contributes to over 40% of cancer cures. Within the last decade, cancer immunotherapy has become a pillar of cancer therapy, along with surgery, chemotherapy, ... -
Dissecting Tumor Response to Radiation Therapy Using Genetically Engineered Mouse Models
(2015)Approximately 50% of all patients with cancer receive radiation therapy at some point during the course of their illness. Despite advances in radiation delivery and treatment planning, normal tissue toxicity often limits ... -
Driving Brain Tumorigenesis: Generation and Biological Characterization of a Mutant IDH1 Mouse Model
(2014)Despite decades worth of research, glioblastoma remains one of the most lethal cancers. The identification of <italic>IDH1</italic> as a major cancer gene in glioblastoma provides an exceptional opportunity for improving ... -
Elucidating the Mechanisms Underlying the Mutational Bias of RAS Genes in Cancer Using a Chemical Carcinogenesis Mouse Model
(2020)Missense oncogenic mutations in the RAS genes are found in around 20% of all human cancers, which are known to be tumorigenic. Despite scores of different oncogenic RAS mutations detected in human cancers, these mutations ...
