Browsing by Subject "Cartilage"
Now showing items 1-13 of 13
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Cartilage Lubrication and Joint Protection by the Glycoprotein PRG4 Studied on the Microscale
(2010)Human joints are able to withstand millions of loading cycles with loads regularly more than 3 times an individual's body weight in large part due to the unique bearing properties of articular cartilage, a strong, slippery ... -
Cellular and Biomaterial Engineering for Orthopaedic Regenerative Medicine
(2015)The ends of long bones that articulate with respect to one another are lined with a crucial connective tissue called articular cartilage. This tissue plays an essential biomechanical function in synovial joints, as it serves ... -
Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix.
(Tissue Eng Part A, 2010-02)OBJECTIVES: Adipose-derived stem cells (ASCs) and bone marrow-derived mesenchymal stem cells (MSCs) are multipotent adult stem cells with potential for use in cartilage tissue engineering. We hypothesized that these cells ... -
Development of Cartilage-Derived Matrix Scaffolds via Crosslinking, Decellularization, and Ice-Templating
(2015)Articular cartilage is a connective tissue that lines the surfaces of diarthrodial joints; and functions to support and distribute loads as wells as facilitate smooth joint articulation. Unfortunately, cartilage possesses ... -
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of ... -
Elucidating the Molecular Architecture of Cartilage by Proteomics
(2015)Articular cartilage is a highly specialized avascular tissue and consists of chondrocytes and two major components, a collagen-rich framework and highly abundant proteoglycans. The chondrocyte morphology and extracellular ... -
First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis.
(PLoS One, 2010-03-17)BACKGROUND: Osteoarthritis (OA) is a debilitating chronic multijoint disease of global proportions. OA presence and severity is usually documented by x-ray imaging but whole body imaging is impractical due to radiation exposure, ... -
In vivo Mechanical Metrics for the Quantitative Assessment of Cartilage Health
(2019)Osteoarthritis (OA) is a common joint disorder, affecting over 27 million Americans. OA is characterized by the degeneration of cartilage tissue, and presents clinically with joint pain, stiffness, and limited range of motion. ... -
Multimodal Musculoskeletal Imaging Techniques to Non-Invasively Assess In Vivo Soft and Hard Tissue Biomechanics
(2022)It is possible to investigate in vivo musculoskeletal biomechanics using multimodal medical imaging techniques; however, the analysis of medical image sets is often time-prohibitive. In this dissertation, I outline various ... -
Neural network analysis identifies scaffold properties necessary for in vitro chondrogenesis in elastin-like polypeptide biopolymer scaffolds.
(Tissue Eng Part A, 2010-01)The successful design of biomaterial scaffolds for articular cartilage tissue engineering requires an understanding of the impact of combinations of material formulation parameters on diverse and competing functional outcomes ... -
Non-Invasive Characterization of Cartilage Properties Using MR Imaging
(2015)Osteoarthritis (OA) is a degenerative disease affecting articular cartilage, leading to loss of its structure and function. Early stage OA is characterized by changes in the extracellular matrix (ECM), including a reduction ... -
Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis.
(PLoS Genet, 2016-10)Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, ... -
Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model.
(PLoS One, 2014)ZDHHC13 is a member of DHHC-containing palmitoyl acyltransferases (PATs) family of enzymes. It functions by post-translationally adding 16-carbon palmitate to proteins through a thioester linkage. We have previously shown ...
