Browsing by Subject "Cell Aging"

Now showing items 1-3 of 3

    • The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans. 

      Lowe, Robert; Overhoff, Marita G; Ramagopalan, Sreeram V; Garbe, James C; Koh, James; Stampfer, Martha R; Beach, David H; ... (9 authors) (Genome Biol, 2015-09-17)
      BACKGROUND: Cellular senescence is a stable arrest of proliferation and is considered a key component of processes associated with carcinogenesis and other ageing-related phenotypes. Here, we perform methylome analysis of ...

    • Utility of telomerase-pot1 fusion protein in vascular tissue engineering. 

      Petersen, Thomas H; Hitchcock, Thomas; Muto, Akihito; Calle, Elizabeth A; Zhao, Liping; Gong, Zhaodi; Gui, Liqiong; ... (11 authors) (Cell Transplant, 2010)
      While advances in regenerative medicine and vascular tissue engineering have been substantial in recent years, important stumbling blocks remain. In particular, the limited life span of differentiated cells that are harvested ...

    • Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition. 

      González-Billalabeitia, Enrique; Seitzer, Nina; Song, Su Jung; Song, Min Sup; Patnaik, Akash; Liu, Xue-Song; Epping, Mirjam T; ... (20 authors) (Cancer discovery, 2014-08)
      Prostate cancer is the most prevalent cancer in males, and treatment options are limited for advanced forms of the disease. Loss of the PTEN and TP53 tumor suppressor genes is commonly observed in prostate cancer, whereas ...