Browsing by Subject "Cell Death"
Now showing items 1-14 of 14
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A genome-wide RNAi screen reveals multiple regulators of caspase activation.
(The Journal of cell biology, 2007-11-12)Apoptosis is an evolutionally conserved cellular suicide mechanism that can be activated in response to a variety of stressful stimuli. Increasing evidence suggests that apoptotic regulation relies on specialized cell death ... -
A plant genetic network for preventing dysbiosis in the phyllosphere.
(Nature, 2020-04-08)The aboveground parts of terrestrial plants, collectively called the phyllosphere, have a key role in the global balance of atmospheric carbon dioxide and oxygen. The phyllosphere represents one of the most abundant habitats ... -
ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury.
(Journal of neuroscience research, 2014-07)Apolipoprotein E (apoE), a plasma protein responsible for transporting lipid and cholesterol, modulates responses of the central nervous system to injury. Small peptides derived from the receptor-binding region of apoE can ... -
Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats.
(Journal of neurophysiology, 2017-07)We have determined the impact of rod death and cone reorganization on the spatiotemporal receptive fields (RFs) and spontaneous activity of distinct retinal ganglion cell (RGC) types. We compared RGC function between healthy ... -
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
(Nature chemical biology, 2005-07)The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms of regulated cell death. Although stimulation of the Fas/TNFR receptor family triggers a canonical ... -
Development of a simplified spinal cord ischemia model in mice.
(Journal of neuroscience methods, 2010-06)Use of genetically manipulated mice facilitates understanding pathological mechanisms in many diseases and contributes to therapy development. However, there is no practical and clinically relevant mouse model available ... -
Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.
(PLoS Genet, 2013-06)Non-autonomous cell-death is a cardinal feature of the disintegration of neural networks in neurodegenerative diseases, but the molecular bases of this process are poorly understood. The neural retina comprises a mosaic ... -
Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair.
(eLife, 2021-07-19)Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic form of regulated cell death that has been implicated in maladaptive renal repair in mice and humans. Using single-cell transcriptomic ... -
Identification of Molecular Determinants of Cellular Senescence in Cancer and Aging
(2018)Cellular senescence is a fundamental cell fate playing significant and complex roles during tumorigenesis and natural aging process. However, the molecular determinants distinguishing senescence from other temporary and ... -
Mitochondrial DNA damage induced autophagy, cell death, and disease.
(Front Biosci (Landmark Ed), 2016-01-01)Mammalian mitochondria contain multiple small genomes. While these organelles have efficient base excision removal of oxidative DNA lesions and alkylation damage, many DNA repair systems that work on nuclear DNA damage are ... -
PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically.
(Nat Med, 2016-01)Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, which encodes a polyglutamine tract in the HTT protein. We found that peroxisome ... -
Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.
(PloS one, 2019-01-09)Standard treatment, unfortunately, yields a poor prognosis for patients with primary or metastatic cancers in the central nervous system, indicating a necessity for novel therapeutic agents. Immunotoxins (ITs) are a class ... -
Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers.
(Nature communications, 2018-10)Intrinsic resistance to anti-HER2 therapy in breast cancer remains an obstacle in the clinic, limiting its efficacy. However, the biological basis for intrinsic resistance is poorly understood. Here we performed ... -
Zfp335-Mediated Regulation of T cell Development
(2022)T cells are a critical arm of the adaptive immune system which function to coordinate and orchestrate complex immune reactions, as well as, kill damaged and infected cells. Production of a diverse peripheral T cell compartment ...
