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Browsing by Subject "Cell Polarity"
Now showing items 1-9 of 9
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Cell-cycle control of cell polarity in yeast.
(The Journal of cell biology, 2019-01)In many cells, morphogenetic events are coordinated with the cell cycle by cyclin-dependent kinases (CDKs). For example, many mammalian cells display extended morphologies during interphase but round up into more spherical ... -
Chemotactic movement of a polarity site enables yeast cells to find their mates.
(Proceedings of the National Academy of Sciences of the United States of America, 2021-06)How small eukaryotic cells can interpret dynamic, noisy, and spatially complex chemical gradients to orient growth or movement is poorly understood. We address this question using Saccharomyces cerevisiae, where cells orient ... -
Exploratory polarization facilitates mating partner selection in Saccharomyces cerevisiae.
(Molecular biology of the cell, 2021-05)Yeast decode pheromone gradients to locate mating partners, providing a model for chemotropism. How yeast polarize toward a single partner in crowded environments is unclear. Initially, cells often polarize in unproductive ... -
How cells determine the number of polarity sites.
(eLife, 2021-04-26)The diversity of cell morphologies arises, in part, through regulation of cell polarity by Rho-family GTPases. A poorly understood but fundamental question concerns the regulatory mechanisms by which different cells generate ... -
Mechanistic insights into actin-driven polarity site movement in yeast.
(Molecular biology of the cell, 2020-05)Directed cell growth or migration are critical for the development and function of many eukaryotic cells. These cells develop a dynamic "front" (also called "polarity site") that can change direction. Polarity establishment ... -
Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells.
(Biomaterials, 2010-02)The growth of stem cells can be modulated by physical factors such as extracellular matrix nanotopography. We hypothesize that nanotopography modulates cell behavior by changing the integrin clustering and focal adhesion ... -
Regulated spindle orientation buffers tissue growth in the epidermis.
(eLife, 2019-10)Tissue homeostasis requires a balance between progenitor cell proliferation and loss. Mechanisms that maintain this robust balance are needed to avoid tissue loss or overgrowth. Here we demonstrate that regulation of spindle ... -
The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells.
(Viruses, 2011-12-21)Many diverse viruses target a polarized epithelial monolayer during host invasion. The polarized epithelium is adept at restricting the movement of solutes, ions, macromolecules, and pathogens across the mucosa. This regulation ... -
UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity.
(J Cell Biol, 2014-09-01)The receptor deleted in colorectal cancer (DCC) directs dynamic polarizing activities in animals toward its extracellular ligand netrin. How DCC polarizes toward netrin is poorly understood. By performing live-cell imaging ...
