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Browsing by Subject "Cerebral Cortex"
Now showing items 1-20 of 35
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A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination.
(Proc Natl Acad Sci U S A, 1993-02-15)We have previously shown that second-messenger-dependent kinases (cAMP-dependent kinase, protein kinase C) in the olfactory system are essential in terminating second-messenger signaling in response to odorants. We now document ... -
A mathematical model for persistent post-CSD vasoconstriction.
(PLoS computational biology, 2020-07-15)Cortical spreading depression (CSD) is the propagation of a relatively slow wave in cortical brain tissue that is linked to a number of pathological conditions such as stroke and migraine. Most of the existing literature ... -
Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues: evidence from functional magnetic resonance imaging.
(Am J Psychiatry, 2002-06)OBJECTIVE: The authors sought to increase understanding of the brain mechanisms involved in cigarette addiction by identifying neural substrates modulated by visual smoking cues in nicotine-deprived smokers. METHOD: Event-related ... -
Advances in understanding mechanisms of thalamic relays in cognition and behavior.
(J Neurosci, 2014-11-12)The main impetus for a mini-symposium on corticothalamic interrelationships was the recent number of studies highlighting the role of the thalamus in aspects of cognition beyond sensory processing. The thalamus contributes ... -
Age-related differences in the neural bases of phonological and semantic processes in the context of task-irrelevant information.
(Cognitive, affective & behavioral neuroscience, 2019-08)As we age we have increasing difficulty with phonological aspects of language production. Yet semantic processes are largely stable across the life span. This suggests a fundamental difference in the cognitive and potentially ... -
Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3.
(PLoS One, 2010-08-20)Angelman syndrome (AS) is a neurobehavioral disorder associated with mental retardation, absence of language development, characteristic electroencephalography (EEG) abnormalities and epilepsy, happy disposition, movement ... -
Basal ganglia function, stuttering, sequencing, and repair in adult songbirds.
(Sci Rep, 2014-10-13)A pallial-basal-ganglia-thalamic-pallial loop in songbirds is involved in vocal motor learning. Damage to its basal ganglia part, Area X, in adult zebra finches has been noted to have no strong effects on song and its function ... -
Bistability and up/down state alternations in inhibition-dominated randomly connected networks of LIF neurons.
(Scientific reports, 2017-09-20)Electrophysiological recordings in cortex in vivo have revealed a rich variety of dynamical regimes ranging from irregular asynchronous states to a diversity of synchronized states, depending on species, anesthesia, and ... -
Brain activity during episodic retrieval of autobiographical and laboratory events: an fMRI study using a novel photo paradigm.
(J Cogn Neurosci, 2004-11)Functional neuroimaging studies of episodic memory retrieval generally measure brain activity while participants remember items encountered in the laboratory ("controlled laboratory condition") or events from their own life ... -
Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection.
(Journal of neurovirology, 2017-06)This study investigated the association of HIV infection and cocaine dependence with cerebral white matter integrity using diffusion tensor imaging (DTI). One hundred thirty-five participants stratified by HIV and cocaine ... -
Coherence potentials: loss-less, all-or-none network events in the cortex.
(PLoS Biol, 2010-01-12)Transient associations among neurons are thought to underlie memory and behavior. However, little is known about how such associations occur or how they can be identified. Here we recorded ongoing local field potential (LFP) ... -
Cortical iron mediates age-related decline in fluid cognition.
(Human brain mapping, 2022-02)Brain iron dyshomeostasis disrupts various critical cellular functions, and age-related iron accumulation may contribute to deficient neurotransmission and cell death. While recent studies have linked excessive brain iron ... -
Development of hemispheric specialization for lexical pitch-accent in Japanese infants.
(J Cogn Neurosci, 2010-11)Infants' speech perception abilities change through the first year of life, from broad sensitivity to a wide range of speech contrasts to becoming more finely attuned to their native language. What remains unclear, however, ... -
Disconnected aging: cerebral white matter integrity and age-related differences in cognition.
(Neuroscience, 2014-09)Cognition arises as a result of coordinated processing among distributed brain regions and disruptions to communication within these neural networks can result in cognitive dysfunction. Cortical disconnection may thus contribute ... -
Drivers from the deep: the contribution of collicular input to thalamocortical processing.
(Prog Brain Res, 2005)A traditional view of the thalamus is that it is a relay station which receives sensory input and conveys this information to cortex. This sensory input determines most of the properties of first order thalamic neurons, ... -
Effective spread and timecourse of neural inactivation caused by lidocaine injection in monkey cerebral cortex.
(J Neurosci Methods, 1997-06-06)We studied the effective spread of lidocaine to inactivate neural tissue in the frontal cortex of the rhesus monkey. Injections of 2% lidocaine at 4 microl/min were made while units were recorded 1 or 2 mm away. To inactivate ... -
Frontal eye field neurons with spatial representations predicted by their subcortical input.
(J Neurosci, 2009-04-22)The frontal eye field (FEF) is a cortical structure involved in cognitive aspects of eye movement control. Neurons in the FEF, as in most of cerebral cortex, primarily represent contralateral space. They fire for visual ... -
Functional modular architecture underlying attentional control in aging.
(NeuroImage, 2017-07)Previous research suggests that age-related differences in attention reflect the interaction of top-down and bottom-up processes, but the cognitive and neural mechanisms underlying this interaction remain an active area ... -
Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.
(J Neurosci, 2014-07-09)Huntington's disease (HD) is a neurodegenerative disease caused by the expansion of a poly-glutamine (poly-Q) stretch in the huntingtin (Htt) protein. Gain-of-function effects of mutant Htt have been extensively investigated ... -
Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye-movement sleep.
(J Neurosci, 2002-12-15)Rapid-eye-movement (REM) sleep plays a key role in the consolidation of memories acquired during waking (WK). The search for mechanisms underlying that role has revealed significant correlations in the patterns of neuronal ...
