Browsing by Subject "Chemistry, Inorganic"
Now showing items 1-9 of 9
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Characterization of Metal Binding Peptides Derived from Copper Trafficking Proteins
(2010)Copper was first released into the environment as the result of the mass generation of oxygen from photosynthetic bacteria roughly 2.7 billion years ago. While it proved to be poisonous to early life on Earth, those that ... -
Copper at the Interface of Chemistry and Biology: New Insights into hCtr1 Function and the Role of Histidine in Human Cellular Copper Acquisition
(2010)Mechanisms of copper homeostasis are of great interest partly due to their connection to debilitating genetic and neurological disorders. The family of high-affinity copper transporters (Ctr) is responsible for extracellular ... -
Design of Photocage Ligands for Light-Activated Changes in Coordination of d-block Transition Metals
(2010)The concept of light-activated "caged" metal ions was first introduced for Ca2+. These high affinity coordination complexes are activated by UV light to release calcium ions intracellularly and have found widespread use ... -
Masked Metal Chelators of Variable Denticity to Prevent Oxidative Stress
(2010)Cellular damage due to oxidative stress is implicated in a wide variety of conditions including degenerative diseases like Alzheimer's and Parkinson's Diseases. One source of oxidative stress is the interaction of redox-active ... -
Molecular Recognition in Host-Guest Ionophore-Siderophore Assemblies
(2010)This work examines the characterization of supramolecular assemblies and, more specifically, host-guest complexes involved in molecular recognition events. The supramolecular assemblies studied take root from metal ion ... -
Physicochemical characterization of chelation and transport of iron by low molecular weight chelators
(2010)The research presented here aims to expand our understanding of the structural factors that contribute to selectivity for iron and to iron complex stability in siderophores, as well as iron transport processes in siderophore ... -
Platinum(II) Species and their Coordination to Amino Acids and Methioine Motifs
(2010)Human and yeast analogs of a high affinity copper transport protein (hCtr1 and yCtr1) have been implicated in the transport of platinum-based drugs in cells. Using liquid chromatography and mass spectrometry, we have compared ... -
Synthesis and Characterization of Second- Generation Iron Pro-chelators
(2010)Excessive amounts of labile metals such as iron, zinc, and copper have been found in the brains of patients diagnosed with various neurodegenerative diseases, which include Alzheimer's and Parkinson's disease. Iron and ... -
Thermodynamic Investigations of Metalloproteins: Metal as Probe and Protein as Probe
(2010)In this dissertation several metalloproteins, both metal transport proteins and the classic metalloprotein hemoglobin, are investigated using a variety of biophysical and electrochemical techniques. In each case, thermodynamic ...
