Browsing by Subject "Chemokine CXCL12"

Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow.

Kelsoe, Garnett; Kondo, M; Ueda, Y (J Exp Med, 2005-06-06)

The coordinated production of leukocytes in bone marrow is crucial for innate and adaptive immunity. Inflammation alters normal leukocyte production by promoting granulopoiesis over lymphopoiesis, a response that supports ...

Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.

Foster, SJ; Kelsoe, Garnett; Kondo, M; Ueda, Y; Yang, K (J Exp Med, 2004-01-05)

Inflammation removes developing and mature lymphocytes from the bone marrow (BM) and induces the appearance of developing B cells in the spleen. BM granulocyte numbers increase after lymphocyte reductions to support a reactive ...

Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery.

Chao, Nelson J; Chhabra, S; Corbet, K; Costa, L; Gasparetto, C; Green, MMB; Horwitz, A; ... (18 authors) (J Hematol Oncol, 2018-03-04)

BACKGROUND: The binding of CXCR4 with its ligand (stromal-derived factor-1) maintains hematopoietic stem/progenitor cells (HSPCs) in a quiescent state. We hypothesized that blocking CXCR4/SDF-1 interaction after hematopoietic ...