Browsing by Subject "Chemokine CXCL12"
Now showing items 1-3 of 3
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Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow.
(J Exp Med, 2005-06-06)The coordinated production of leukocytes in bone marrow is crucial for innate and adaptive immunity. Inflammation alters normal leukocyte production by promoting granulopoiesis over lymphopoiesis, a response that supports ... -
Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.
(J Exp Med, 2004-01-05)Inflammation removes developing and mature lymphocytes from the bone marrow (BM) and induces the appearance of developing B cells in the spleen. BM granulocyte numbers increase after lymphocyte reductions to support a reactive ... -
Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery.
(J Hematol Oncol, 2018-03-04)BACKGROUND: The binding of CXCR4 with its ligand (stromal-derived factor-1) maintains hematopoietic stem/progenitor cells (HSPCs) in a quiescent state. We hypothesized that blocking CXCR4/SDF-1 interaction after hematopoietic ...