Browsing by Subject "Chlamydia"
Now showing items 1-14 of 14
-
Chlamydia Subversion of Host Lipid Transport: Interactions with Cytoplasmic Lipid Droplets
(2009)The <italic>Chlamydiaceae</italic> are Gram-negative, obligate intracellular bacteria that are significant pathogens of humans and animals. Intracellularly, the bacteria reside in a membrane-bound vacuole, called the inclusion, ... -
Components of the Host-Pathogen Interface and Their Role in Chlamydial Intracellular Pathogenesis
(2023)Intracellular bacteria such as Chlamydia inhabit a single-membrane vacuolar compartment termed the “inclusion”. Chlamydia inclusions offer an escape from host immune defenses and a dedicated spaces for replication. Viable ... -
Defining the Role of Host Cell Chromatin Traps in Chlamydia trachomatis Pathogenesis
(2016)Chlamydia trachomatis (CT) is the most common bacterial agent of sexually transmitted infection and can cause damaging inflammation of the female reproductive tract. As an obligate intracellular pathogen, CT must exit exhausted ... -
Examination of Menaquinone Biosynthesis Genes in Chlamydia trachomatis
(2018)The obligated intracellular bacterium Chlamydia trachomatis is a pathogen of immense clinical and societal importance with over 1.5 million cases of new infection reported annually in the United States alone. With asymptomatic ... -
Functional Characterization of Type II Secretion in Chlamydia
(2017)Chlamydiae are obligate intracellular bacteria that infect a wide range of animal hosts. For a successful infection, interaction with the host cell by use of the type II (T2), type III (T3), and type V (T5) secretion systems ... -
Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture.
(mBio, 2019-04-09)Interferon-regulated immune defenses protect mammals from pathogenically diverse obligate intracellular bacterial pathogens of the genus Chlamydia Interferon gamma (IFN-γ) is especially important in controlling the virulence ... -
Insights into Chlamydial Protease-Like Activity Factor (CPAF)
(2011)During infection of epithelial cells, the obligate intracellular pathogen Chlamydia trachomatis secretes the serine protease chlamydial protease-like activity factor (CPAF) into the host cytosol to regulate a range of host ... -
Mechanisms of Chlamydia manipulation of host cell biology revealed through genetic approaches
(2015)Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and is the leading cause of preventable blindness worldwide. Chlamydia is particularly intriguing from the perspective of cell biology because ... -
Murine Immunity-Related GTPase M Proteins Regulate Immunity to Intracellular Infections
(2021)Host cells are equipped with a robust defense program to defend against intracellular pathogens. The cytokine gamma-interferon (IFNg) activates expression of hundreds of genes that identify intracellular pathogens such as ... -
Search for microRNAs expressed by intracellular bacterial pathogens in infected mammalian cells.
(PLoS One, 2014)MicroRNAs are expressed by all multicellular organisms and play a critical role as post-transcriptional regulators of gene expression. Moreover, different microRNA species are known to influence the progression of a range ... -
The C. trachomatis effector protein TepP hijacks host cell signaling pathways to promote bacterial survival during infection.
(2017)Chlamydia trachomatis is a bacterial pathogen with a large socioeconomic impact: it is the leading cause of preventable blindness worldwide, and the most prevalent sexually transmitted infection in the United States. Despite ... -
The Chlamydia trachomatis Protease CPAF Regulates Secreted Bacterial Effectors and Host Proteins Essential to Virulence
(2011)<italic>Chlamydia<italic> <italic>trachomatis<italic> remains a highly relevant clinical pathogen as it is the causative agent of the most commonly reported sexually transmitted disease in the western hemisphere, and the ... -
The Chlamydia Trachomatis Protein Interaction Network: Insights into the Unique Composition of the Type Three Secretion System
(2008-11-19)The Gram-negative bacteria Chlamydia trachomatis is a common sexually transmitted pathogen that can cause severe sequelae including cause pelvic inflammatory disease and sterility. This obligate intracellular pathogen ... -
The Phospholipase cPLA2 Regulates the Expression of Type I Intereferons and Intracellular Immunity to Chlamydia Trachomatis
(2009)When bacterial pathogens infect their hosts, they illicit responses intended on containing and eliminating these invaders. This happens not only on the organismal level, but also on the cellular level. When a cell detects ...
