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Browsing by Subject "Chromatin Assembly and Disassembly"
Now showing items 1-4 of 4
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Chromatin Remodeling of Colorectal Cancer Liver Metastasis is Mediated by an HGF-PU.1-DPP4 Axis.
(Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021-10)Colorectal cancer (CRC) metastasizes mainly to the liver, which accounts for the majority of CRC-related deaths. Here it is shown that metastatic cells undergo specific chromatin remodeling in the liver. Hepatic growth factor ... -
Functional epialleles at an endogenous human centromere.
(Proc Natl Acad Sci U S A, 2012-08-21)Human centromeres are defined by megabases of homogenous alpha-satellite DNA arrays that are packaged into specialized chromatin marked by the centromeric histone variant, centromeric protein A (CENP-A). Although most human ... -
Genes with high penetrance for syndromic and non-syndromic autism typically function within the nucleus and regulate gene expression.
(Molecular autism, 2016-01)BACKGROUND:Intellectual disability (ID), autism, and epilepsy share frequent yet variable comorbidities with one another. In order to better understand potential genetic divergence underlying this variable risk, we studied ... -
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.
(Nature, 2013-06-13)DNA damage activates a signalling network that blocks cell-cycle progression, recruits DNA repair factors and/or triggers senescence or programmed cell death. Alterations in chromatin structure are implicated in the initiation ...
