Now showing items 1-2 of 2

    • Functional epialleles at an endogenous human centromere. 

      Ferris, A; Maloney, KA; Matheny, JE; Merrett, SL; Strome, ED; Sullivan, Beth Ann; Sullivan, LL (Proc Natl Acad Sci U S A, 2012-08-21)
      Human centromeres are defined by megabases of homogenous alpha-satellite DNA arrays that are packaged into specialized chromatin marked by the centromeric histone variant, centromeric protein A (CENP-A). Although most human ...
    • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 

      Blake, EJ; Bradner, JE; Bryson, BD; Cannell, IG; Carpenter, AE; Chen, CC; Chen, GC; ... (24 authors) (Nature, 2013-06-13)
      DNA damage activates a signalling network that blocks cell-cycle progression, recruits DNA repair factors and/or triggers senescence or programmed cell death. Alterations in chromatin structure are implicated in the initiation ...