Browsing by Subject "Chromosomes, Fungal"

Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation.

Janbon, G; Ormerod, KL; Paulet, D; Byrnes, EJ; Yadav, V; Chatterjee, G; Mullapudi, N; ... (52 authors) (PLoS Genet, 2014-04)

Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than 600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties (i.e. grubii and neoformans, respectively). ...

How the kinetochore couples microtubule force and centromere stretch to move chromosomes.

Suzuki, Aussie; Badger, Benjamin L; Haase, Julian; Ohashi, Tomoo; Erickson, Harold P; Salmon, Edward D; Bloom, Kerry (Nature cell biology, 2016-04)

The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and for force generation coupled to plus-end polymerization ...

Morphological and genomic characterization of Filobasidiella depauperata: a homothallic sibling species of the pathogenic cryptococcus species complex.

Rodriguez-Carres, Marianela; Findley, Keisha; Sun, Sheng; Dietrich, Fred S; Heitman, Joseph (PLoS One, 2010-03-10)

The fungal species Cryptococcus neoformans and Cryptococcus gattii cause respiratory and neurological disease in animals and humans following inhalation of basidiospores or desiccated yeast cells from the environment. Sexual ...

Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients.

Hu, Guanggan; Wang, Joyce; Choi, Jaehyuk; Jung, Won Hee; Liu, Iris; Litvintseva, Anastasia P; Bicanic, Tihana; ... (11 authors) (BMC Genomics, 2011-10-27)

BACKGROUND: The adaptation of pathogenic fungi to the host environment via large-scale genomic changes is a poorly characterized phenomenon. Cryptococcus neoformans is the leading cause of fungal meningoencephalitis in HIV/AIDS ...