Browsing by Subject "Chromosomes, Human, X"
Now showing items 1-4 of 4
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High-resolution microarray analysis unravels complex Xq28 aberrations in patients and carriers affected by X-linked blue cone monochromacy.
(Clin Genet, 2016-01)The human X chromosome contains ∼ 1600 genes, about 15% of which have been associated with a specific genetic condition, mainly affecting males. Blue cone monochromacy (BCM) is an X-linked condition caused by a loss-of-function ... -
Histone modifications within the human X centromere region.
(PLoS One, 2009-08-12)Human centromeres are multi-megabase regions of highly ordered arrays of alpha satellite DNA that are separated from chromosome arms by unordered alpha satellite monomers and other repetitive elements. Complexities in assembling ... -
Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association.
(PLoS Genet, 2014-11)Associating genetic variation with quantitative measures of gene regulation offers a way to bridge the gap between genotype and complex phenotypes. In order to identify quantitative trait loci (QTLs) that influence the binding ... -
Unmasking a role for sex chromosomes in gene silencing.
(Genome Biol, 2010)Several sexually dimorphic phenotypes correlate with sex-chromosome dosage rather than with phenotypic sex. New research suggests that sex chromosome dimorphism helps to regulate gene silencing.
