Now showing items 1-9 of 9

    • Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254). 

      Catterall, JB; Flannery, CR; Kraus, Virginia Byers; Stabler, Thomas (Arthritis Res Ther, 2010)
      INTRODUCTION: Acute trauma involving the anterior cruciate ligament is believed to be a major risk factor for the development of post-traumatic osteoarthritis 10 to 20 years post-injury. In this study, to better understand ...
    • Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis. 

      Bunte, RM; Crowley, Steven Daniel; Griffiths, Robert; Madan, B; Patel, MB; Rudemiller, Nathan P; Virshup, DM; ... (8 authors) (Kidney Int, 2016-05)
      Activated Wnt signaling is critical in the pathogenesis of renal fibrosis, a final common pathway for most forms of chronic kidney disease. Therapeutic intervention by inhibition of individual Wnts or downstream Wnt/β-catenin ...
    • Functional outcome measures in a surgical model of hip osteoarthritis in dogs. 

      Little, Dianne; Johnson, Stephen; Hash, J; Olson, Steven Arthur; Estes, Bradley; Moutos, Franklin; Lascelles, BDX; ... (8 authors) (J Exp Orthop, 2016-12)
      BACKGROUND: The hip is one of the most common sites of osteoarthritis in the body, second only to the knee in prevalence. However, current animal models of hip osteoarthritis have not been assessed using many of the functional ...
    • Functional properties of cell-seeded three-dimensionally woven poly(epsilon-caprolactone) scaffolds for cartilage tissue engineering. 

      Guilak, Farshid; Moutos, Franklin (Tissue Eng Part A, 2010-04)
      Articular cartilage possesses complex mechanical properties that provide healthy joints the ability to bear repeated loads and maintain smooth articulating surfaces over an entire lifetime. In this study, we utilized ...
    • Ligament-derived matrix stimulates a ligamentous phenotype in human adipose-derived stem cells. 

      Guilak, Farshid; Little, Dianne; Ruch, DS (Tissue Eng Part A, 2010-07)
      Human adipose stem cells (hASCs) can differentiate into a variety of phenotypes. Native extracellular matrix (e.g., demineralized bone matrix or small intestinal submucosa) can influence the growth and differentiation of ...
    • Mechanobiology of the meniscus. 

      Guilak, Farshid; McNulty, Amy (J Biomech, 2015-06-01)
      The meniscus plays a critical biomechanical role in the knee, providing load support, joint stability, and congruity. Importantly, growing evidence indicates that the mechanobiologic response of meniscal cells plays a critical ...
    • The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants. 

      Brown, NL; Klitzman, Bruce; Koh, A; Nichols, Scott P; Riccio, DA; Rose, MB; Schoenfisch, MH; ... (9 authors) (Biomaterials, 2012-09)
      Although the release of nitric oxide (NO) from biomaterials has been shown to reduce the foreign body response (FBR), the optimal NO release kinetics and doses remain unknown. Herein, polyurethane-coated wire substrates ...
    • Utility of telomerase-pot1 fusion protein in vascular tissue engineering. 

      Petersen, TH; Hitchcock, T; Muto, A; Calle, EA; Zhao, L; Gong, Z; Gui, L; ... (11 authors) (Cell Transplant, 2010)
      While advances in regenerative medicine and vascular tissue engineering have been substantial in recent years, important stumbling blocks remain. In particular, the limited life span of differentiated cells that are harvested ...
    • Vesicoureteral reflux and the extracellular matrix connection. 

      Brophy, PD; Gbadegesin, Rasheed Adebayo; Gupta, IR; Tokhmafshan, F (Pediatr Nephrol, 2016-05-02)
      Primary vesicoureteral reflux (VUR) is a common pediatric condition due to a developmental defect in the ureterovesical junction. The prevalence of VUR among individuals with connective tissue disorders, as well as the importance ...