Browsing by Subject "Cryptococcosis"
Now showing items 1-15 of 15
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Analyses of pediatric isolates of Cryptococcus neoformans from South Africa.
(J Clin Microbiol, 2011-01)Compared to the incidence in adults, cryptococcosis is inexplicably rare among children, even in sub-Saharan Africa, which has the highest prevalence of coinfection with HIV and Cryptococcus neoformans. To explore any mycological ... -
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
(Clin Infect Dis, 2010-02-01)Cryptococcosis is a global invasive mycosis associated with significant morbidity and mortality. These guidelines for its management have been built on the previous Infectious Diseases Society of America guidelines from ... -
Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana.
(Mol Ecol, 2015-07)Cryptococcus neoformans var. grubii (Cng) is the most common cause of fungal meningitis, and its prevalence is highest in sub-Saharan Africa. Patients become infected by inhaling airborne spores or desiccated yeast cells ... -
Cryptococcal cell morphology affects host cell interactions and pathogenicity.
(PLoS Pathog, 2010-06-17)Cryptococcus neoformans is a common life-threatening human fungal pathogen. The size of cryptococcal cells is typically 5 to 10 microm. Cell enlargement was observed in vivo, producing cells up to 100 microm. These morphological ... -
Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal.
(PLoS Pathog, 2014-08)Ongoing Cryptococcus gattii outbreaks in the Western United States and Canada illustrate the impact of environmental reservoirs and both clonal and recombining propagation in driving emergence and expansion of microbial ... -
Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States.
(PLoS Pathog, 2010-04-22)Cryptococcus gattii causes life-threatening disease in otherwise healthy hosts and to a lesser extent in immunocompromised hosts. The highest incidence for this disease is on Vancouver Island, Canada, where an outbreak is ... -
Etiologies of illness among patients meeting integrated management of adolescent and adult illness district clinician manual criteria for severe infections in northern Tanzania: implications for empiric antimicrobial therapy.
(Am J Trop Med Hyg, 2015-02)We describe the laboratory-confirmed etiologies of illness among participants in a hospital-based febrile illness cohort study in northern Tanzania who retrospectively met Integrated Management of Adolescent and Adult Illness ... -
Evidence that the human pathogenic fungus Cryptococcus neoformans var. grubii may have evolved in Africa.
(PLoS One, 2011-05-11)Most of the species of fungi that cause disease in mammals, including Cryptococcus neoformans var. grubii (serotype A), are exogenous and non-contagious. Cryptococcus neoformans var. grubii is associated worldwide with avian ... -
Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
(Nature communications, 2019-09)Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA) ... -
Let's talk about sex characteristics-As a risk factor for invasive fungal diseases.
(Mycoses, 2022-06)Biological sex, which comprises differences in host sex hormone homeostasis and immune responses, can have a substantial impact on the epidemiology of infectious diseases. Comprehensive data on sex distributions in invasive ... -
Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion.
(MBio, 2015-09-29)UNLABELLED: The human fungal pathogen Cryptococcus neoformans is capable of infecting a broad range of hosts, from invertebrates like amoebas and nematodes to standard vertebrate models such as mice and rabbits. Here we ... -
Unrecognized pretransplant and donor‐derived cryptococcal disease in organ transplant recipients.
(Clin Infect Dis, 2010-11-01)BACKGROUND: Cryptococcosis occurring ≤30 days after transplantation is an unusual event, and its characteristics are not known. METHODS: Patients included 175 solid-organ transplant (SOT) recipients with cryptococcosis in ... -
Unveiling Protein Kinase A Targets in Cryptococcus neoformans Capsule Formation.
(MBio, 2016-02-09)The protein kinase A (PKA) signal transduction pathway has been associated with pathogenesis in many fungal species. Geddes and colleagues [mBio 7(1):e01862-15, 2016, doi:10.1128/mBio.01862-15] used quantitative proteomics ... -
Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients.
(BMC Genomics, 2011-10-27)BACKGROUND: The adaptation of pathogenic fungi to the host environment via large-scale genomic changes is a poorly characterized phenomenon. Cryptococcus neoformans is the leading cause of fungal meningoencephalitis in HIV/AIDS ...
