Browsing by Subject "Cryptococcus"
Now showing items 1-9 of 9
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Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species Complex.
(PLoS Genet, 2016-03)RNAi is a ubiquitous pathway that serves central functions throughout eukaryotes, including maintenance of genome stability and repression of transposon expression and movement. However, a number of organisms have lost their ... -
Genome evolution in the fungal pathogen Cryptococcus deuterogattii
(2017)One of the key challenges of the 21st century is the emergence and reemergence of pathogens. Fungal pathogens represent an important portion of this problem, as the cohort of immunocompromised patients susceptible to common ... -
Genome-wide Analyses of Recombination and the Genetic Architecture of Virulence Traits in Cryptococcus
(2020)Fungi of the basidiomycete genus Cryptococcus cause disease in an estimated quarter of a million people, annually. Cryptococcus neoformans and Cryptococcus deneoformans are the two most prevalent disease causing species ... -
Morphological and genomic characterization of Filobasidiella depauperata: a homothallic sibling species of the pathogenic cryptococcus species complex.
(PLoS One, 2010-03-10)The fungal species Cryptococcus neoformans and Cryptococcus gattii cause respiratory and neurological disease in animals and humans following inhalation of basidiospores or desiccated yeast cells from the environment. Sexual ... -
Ras1-mediated Morphogenesis in the Human Fungal Pathogen Cryptococcus Neoformans
(2012)<italic>Cryptococcus neoformans</italic> pathogenesis results from the proliferation of yeast-phase fungal cells within the human host. The Ras1 signal transduction cascade is a major regulator of <italic>C. neoformans</italic> ... -
Sex in Cryptococcus: Signaling, Mating-type Locus Evolution and Gene Silencing
(2008-02-26)Fungi have a genetically controlled sex determination system, which is governed by a small, sex-specific region in the genome called the mating-type locus (MAT). In the basidiomycetous yeast Cryptococcus neoformans, the ... -
Tissue-Resident Macrophages in Fungal Infections.
(Frontiers in immunology, 2017-01)Invasive fungal infections result in high morbidity and mortality. Host organs targeted by fungal pathogens vary depending on the route of infection and fungal species encountered. Cryptococcus neoformans infects the respiratory ... -
Unrecognized pretransplant and donor‐derived cryptococcal disease in organ transplant recipients.
(Clin Infect Dis, 2010-11-01)BACKGROUND: Cryptococcosis occurring ≤30 days after transplantation is an unusual event, and its characteristics are not known. METHODS: Patients included 175 solid-organ transplant (SOT) recipients with cryptococcosis in ... -
Use of Comparative Genomics for Non-coding Rna Prediction and Investigation of Dna Introgression in Yeast
(2008-04-23)The rapid development of large-scale genomic sequencing has dramatically changed the field of genetics, in part through the development of comparative genomics. Fungal comparative genomics is particularly powerful given ...
