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Browsing by Subject "Cryptococcus neoformans"
Now showing items 1-20 of 33
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A Wor1-Like Transcription Factor Is Essential for Virulence of Cryptococcus neoformans.
(Frontiers in Cellular and Infection Microbiology, 2018-01)Gti1/Pac2 transcription factors occur exclusively in fungi and their roles vary according to species, including regulating morphological transition and virulence, mating and secondary metabolism. Many of these functions ... -
AIDS‐associated Cryptococcus neoformans and Penicillium marneffei coinfection: a therapeutic dilemma in resource‐limited settings.
(Clin Infect Dis, 2010-11-01)AIDS‐associated Cryptococcus neoformans and Penicillium marneffei coinfection has not been adequately studied and poses unique therapeutic challenges in resource‐limited settings. Itraconazole poorly penetrates ... -
Analyses of pediatric isolates of Cryptococcus neoformans from South Africa.
(J Clin Microbiol, 2011-01)Compared to the incidence in adults, cryptococcosis is inexplicably rare among children, even in sub-Saharan Africa, which has the highest prevalence of coinfection with HIV and Cryptococcus neoformans. To explore any mycological ... -
Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation.
(PLoS Genet, 2014-04)Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than 600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties (i.e. grubii and neoformans, respectively). ... -
C. elegans germline-deficient mutants respond to pathogen infection using shared and distinct mechanisms.
(PLoS One, 2010-07-26)Reproduction extracts a cost in resources that organisms are then unable to utilize to deal with a multitude of environmental stressors. In the nematode C. elegans, development of the germline shortens the lifespan of the ... -
Case 4: Weakness and Headaches in a 14-year-old Boy.
(Pediatrics in review, 2018-08) -
Cellular Coordinators: Mechanisms by Which Non-Enzymatic Proteins Contribute to Growth and Cell Surface Remodeling in the Human Fungal Pathogen Cryptococcus neoformans
(2022)My thesis work has focused on characterizing mechanisms by which human fungal pathogens regulate their adaptive cellular responses in order to survive and cause disease in the human host. Unlike most microbial fungi found ... -
Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana.
(Mol Ecol, 2015-07)Cryptococcus neoformans var. grubii (Cng) is the most common cause of fungal meningitis, and its prevalence is highest in sub-Saharan Africa. Patients become infected by inhaling airborne spores or desiccated yeast cells ... -
Cryptococcal cell morphology affects host cell interactions and pathogenicity.
(PLoS Pathog, 2010-06-17)Cryptococcus neoformans is a common life-threatening human fungal pathogen. The size of cryptococcal cells is typically 5 to 10 microm. Cell enlargement was observed in vivo, producing cells up to 100 microm. These morphological ... -
Cryptococcus Neoformans Interactions with Surfactant Proteins: Implications for Innate Pulmonary Immunity
(2009)Concurrent with the global escalation of the AIDS pandemic, cryptococcal infections are increasing and are of significant medical importance. Although improvements in antifungal therapy have advanced the treatment ... -
Cryptococcus neoformans transcriptional regulation of the host-pathogen interface
(2013)<italic>Cryptococcus neoformans </italic>is a human fungal pathogen that is also ubiquitous in the environment. To cause disease inside a human host, <italic>C. neoformans</italic> must be able to sense and respond to a ... -
Environmental predictors and incubation period of AIDS-associated penicillium marneffei infection in Ho Chi Minh City, Vietnam.
(Clin Infect Dis, 2013-05)BACKGROUND: Penicillium marneffei is an emerging dimorphic mycosis endemic in Southeast Asia, and a leading cause of mortality among human immunodeficiency virus (HIV)-infected people in the region. Factors governing the ... -
Evidence that the human pathogenic fungus Cryptococcus neoformans var. grubii may have evolved in Africa.
(PLoS One, 2011-05-11)Most of the species of fungi that cause disease in mammals, including Cryptococcus neoformans var. grubii (serotype A), are exogenous and non-contagious. Cryptococcus neoformans var. grubii is associated worldwide with avian ... -
Ferrochelatase is a conserved downstream target of the blue light-sensing White collar complex in fungi.
(Microbiology, 2010-08)Light is a universal signal perceived by organisms, including fungi, in which light regulates common and unique biological processes depending on the species. Previous research has established that conserved proteins, originally ... -
Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
(Nature communications, 2019-09)Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA) ... -
Identification of cyclosporin C from Amphichorda felina using a Cryptococcus neoformans differential temperature sensitivity assay.
(Applied microbiology and biotechnology, 2018-03)We used a temperature differential assay with the opportunistic fungal pathogen Cryptococcus neoformans as a simple screening platform to detect small molecules with antifungal activity in natural product extracts. By screening ... -
Identifying the Connection between the Cell Surface and pH-Sensing in a Human Fungal Pathogen
(2020)Stress tolerance and adaptability to dynamic environments are two things that make a microbial pathogen especially dangerous in the setting of a human infection. Cryptococcus neoformans, a ubiquitous pathogenic fungus, is ... -
Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule.
(PLoS Pathog, 2010-02-19)Cryptococcus neoformans is a prevalent human fungal pathogen that must survive within various tissues in order to establish a human infection. We have identified the C. neoformans Rim101 transcription factor, a highly conserved ... -
Investigating Transcription Factor Networks That Drive Biological Clocks and Oscillators
(2017)Biological systems are highly dynamic, yet our temporal resolution of suchdynamical processes is often limited or difficult to test in the laboratory. The 24-hourcircadian rhythm and the approximately 75-minute cell cycle ... -
Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries.
(The Lancet. Infectious Diseases, 2019-04)In 2018, WHO issued guidelines for the diagnosis, prevention, and management of HIV-related cryptococcal disease. Two strategies are recommended to reduce the high mortality associated with HIV-related cryptococcal meningitis ...
