Browsing by Subject "Cyclin-Dependent Kinase Inhibitor p16"

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The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.

Lowe, Robert; Overhoff, Marita G; Ramagopalan, Sreeram V; Garbe, James C; Koh, James; Stampfer, Martha R; Beach, David H; ... (9 authors) (Genome Biol, 2015-09-17)

BACKGROUND: Cellular senescence is a stable arrest of proliferation and is considered a key component of processes associated with carcinogenesis and other ageing-related phenotypes. Here, we perform methylome analysis of ...