Browsing by Subject "Cystic Fibrosis Transmembrane Conductance Regulator"
Now showing items 1-4 of 4
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A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.
(Proc Natl Acad Sci U S A, 1998-07-21)The Na+/H+ exchanger regulatory factor (NHERF) binds to the tail of the beta2-adrenergic receptor and plays a role in adrenergic regulation of Na+/H+ exchange. NHERF contains two PDZ domains, the first of which is required ... -
A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter.
(J Cell Mol Med, 2009-04)Genes can maintain spatiotemporal expression patterns by long-range interactions between cis-acting elements. The cystic fibrosis transmembrane conductance regulator gene (CFTR) is expressed primarily in epithelial cells. ... -
Regionally distinct progenitor cells in the lower airway give rise to neuroendocrine and multiciliated cells in the developing human lung.
(Proceedings of the National Academy of Sciences of the United States of America, 2023-06)Using scRNA-seq and microscopy, we describe a cell that is enriched in the lower airways of the developing human lung and identified by the unique coexpression of SCGB3A2/SFTPB/CFTR. To functionally interrogate these cells, ... -
Understanding Cystic Fibrosis Transmembrane Conductance Regulator expression in Heart Failure
(2019-04-22)Cardiovascular disease, specifically congestive heart failure, is a leading cause of death in the United States. Cystic Fibrosis (CF) is caused by the mutations to the cystic fibrosis transmembrane conductance regulator ...
