Browsing by Subject "DNA damage"
Now showing items 1-10 of 10
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A mitotic DNA damage response requiring FANCD2 enables mitosis with broken DNA
(2017)In order to maintain genome integrity cells employ a set of well conserved DNA damage checkpoints. DNA damage checkpoints are active during interphase and serve to prevent mitosis with broken DNA. Mitosis with broken DNA ... -
Establishment of Oncogene-Induced Senescence by the Host DNA Damage Response After EBV Infection
(2018)Epstein-Barr virus (EBV) is an oncogenic gamma-herpesvirus that infects over 90% of adults worldwide. Typically, EBV establishes a benign latent infection that is controlled by a strong cytotoxic T cell immune response. ... -
Later Life Consequences of Developmental Mitochondrial DNA Damage in C. elegans
(2015)Mitochondria are responsible for producing the vast majority of cellular ATP, and are therefore critical to organismal health [1]. They contain thir own genomes (mtDNA) which encode 13 proteins that are all subunits of the ... -
Later-life Effects of Mitochondrial DNA Damage During Development in the Whole Organism Model Caenorhabditis elegans
(2012)Early life exposure to mitochondrial toxicants, including paraquat, rotenone, and manganese, has been hypothesized to promote early onset of genetic mitochondrial disorders as well as common degenerative diseases such as ... -
PCR-Based Analysis of Mitochondrial DNA Copy Number, Mitochondrial DNA Damage, and Nuclear DNA Damage.
(Curr Protoc Toxicol, 2016-02-01)Because of the role that DNA damage and depletion play in human disease, it is important to develop and improve tools to assess these endpoints. This unit describes PCR-based methods to measure nuclear and mitochondrial ... -
Re-replication in the Absence of Replication Licensing Mechanisms in Drosophila Melanogaster
(2011)To ensure genomic integrity, the genome must be accurately duplicated once and only once per cell division. DNA replication is tightly regulated by replication licensing mechanisms which ensure that origins only initiate ... -
Regulation of the DNA Damage Response and Spindle Checkpoint Signaling Pathways
(2015)The ultimate goal of any living cell is to pass on a complete, unaltered copy of its DNA to its daughter cell. The DNA damage response (DDR) and spindle checkpoint are two essential signaling pathways that make it possible ... -
The Intersection of DNA Damage Response and Ferroptosis-A Rationale for Combination Therapeutics.
(Biology, 2020-07-23)Ferroptosis is a novel form of iron-dependent cell death characterized by lipid peroxidation. While the importance and disease relevance of ferroptosis are gaining recognition, much remains unknown about its interaction ... -
TRAF Regulation of Caspase-2-Dependent Apoptosis in Response to DNA Damage
(2016)The DNA of a cell operates as its blueprint, providing coded information for the production of the RNA and proteins that allow the cell to function. Cells can face a myriad of insults to their genomic integrity during their ...
