Now showing items 1-8 of 8

    • A nucleosome-guided map of transcription factor binding sites in yeast. 

      Narlikar, Leelavati; Gordân, Raluca; Hartemink, Alexander J (PLoS Comput Biol, 2007-11)
      Finding functional DNA binding sites of transcription factors (TFs) throughout the genome is a crucial step in understanding transcriptional regulation. Unfortunately, these binding sites are typically short and degenerate, ...
    • Analyses of pediatric isolates of Cryptococcus neoformans from South Africa. 

      Miglia, Kathleen J; Govender, Nelesh P; Rossouw, Jenny; Meiring, Susan; Mitchell, Thomas G; Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (J Clin Microbiol, 2011-01)
      Compared to the incidence in adults, cryptococcosis is inexplicably rare among children, even in sub-Saharan Africa, which has the highest prevalence of coinfection with HIV and Cryptococcus neoformans. To explore any mycological ...
    • Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. 

      Janbon, Guilhem; Ormerod, Kate L; Paulet, Damien; Byrnes, Edmond J; Yadav, Vikas; Chatterjee, Gautam; Mullapudi, Nandita; ... (52 authors) (PLoS Genet, 2014-04)
      Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than 600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties (i.e. grubii and neoformans, respectively). ...
    • Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana. 

      Chen, Yuan; Litvintseva, Anastasia P; Frazzitta, Aubrey E; Haverkamp, Miriam R; Wang, Liuyang; Fang, Charles; Muthoga, Charles; ... (9 authors) (Mol Ecol, 2015-07)
      Cryptococcus neoformans var. grubii (Cng) is the most common cause of fungal meningitis, and its prevalence is highest in sub-Saharan Africa. Patients become infected by inhaling airborne spores or desiccated yeast cells ...
    • Evidence that the human pathogenic fungus Cryptococcus neoformans var. grubii may have evolved in Africa. 

      Litvintseva, Anastasia P; Carbone, Ignazio; Rossouw, Jenny; Thakur, Rameshwari; Govender, Nelesh P; Mitchell, Thomas G (PLoS One, 2011-05-11)
      Most of the species of fungi that cause disease in mammals, including Cryptococcus neoformans var. grubii (serotype A), are exogenous and non-contagious. Cryptococcus neoformans var. grubii is associated worldwide with avian ...
    • Evidence-ranked motif identification. 

      Boyle, AP; Ding, X; Georgiev, S; Jayasurya, K; Mukherjee, Sayan; Ohler, Uwe (Genome Biol, 2010)
      cERMIT is a computationally efficient motif discovery tool based on analyzing genome-wide quantitative regulatory evidence. Instead of pre-selecting promising candidate sequences, it utilizes information across all sequence ...
    • Pulmonary blastomycosis presenting as primary lung cancer. 

      Hussaini, Syed Mohammed Qasim; Madut, Deng; Tong, Betty C; Pavlisko, Elizabeth N; Schell, Wiley A; Perfect, John R; Thielman, Nathan M (BMC infectious diseases, 2018-07-18)
      BACKGROUND:Blastomycosis is an endemic mycosis in North America that is caused by the dimorphic fungus Blastomyces dermatitidis. The illness is a systemic disease with a wide variety of pulmonary and extra-pulmonary ...
    • Structure, function, and phylogeny of the mating locus in the Rhizopus oryzae complex. 

      Gryganskyi, Andrii P; Lee, Soo Chan; Litvintseva, Anastasia P; Smith, Matthew E; Bonito, Gregory; Porter, Teresita M; Anishchenko, Iryna M; ... (9 authors) (PLoS One, 2010-12-09)
      The Rhizopus oryzae species complex is a group of zygomycete fungi that are common, cosmopolitan saprotrophs. Some strains are used beneficially for production of Asian fermented foods but they can also act as opportunistic ...