Browsing by Subject "DNase-seq"
Now showing items 1-4 of 4
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A Bayesian Model for Nucleosome Positioning Using DNase-seq Data
(2015)As fundamental structural units of the chromatin, nucleosomes are involved in virtually all aspects of genome function. Different methods have been developed to map genome-wide nucleosome positions, including MNase-seq and ... -
Genome-wide Analysis of Chromatin Structure across Diverse Human Cell Types
(2013)Chromatin structure plays an important role in gene regulation, especially in differentiating the diverse cell types in humans. In this dissertation, we analyze the nucleosome positioning and open chromatin profiles genome-wide ... -
Genome-wide Cross-species Analysis Linking Open Chromatin, Differential Expression and Positive Selection
(2012)Deciphering the molecular mechanisms driving the phenotypic differences between humans and primates remains a daunting challenge. Mutations found in protein coding DNA alone has not been able to explain these phenotypic ... -
Modeling Nuclease Digestion Data to Predict the Dynamics of Genome-wide Transcription Factor Occupancy
(2016)Identifying and deciphering the complex regulatory information embedded in the genome is critical to our understanding of biology and the etiology of complex diseases. The regulation of gene expression is governed largely ...
