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Browsing by Subject "Dengue"
Now showing items 1-13 of 13
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A Comprehensive Needs Assessment to Identify Priority Program Targets for Mosquito Vector Control and related Diseases in Belmopan, Belize
(2017)This was a mixed-methods study aimed to comprehensively assess factors associated with mosquito control in Belmopan, Belize, in order to better inform stakeholders on the effectiveness of their efforts. A knowledge, attitudes, ... -
Characterization of Host Factors and Anti-viral Compounds for Diverse Mosquito-borne Flaviviruses
(2016)Our ability to convert basic knowledge into robust anti-viral therapeutics requires discovery of novel host-virus interactions as well as an informed anti-viral discovery pipeline. We used a genome-scale RNAi-based screen ... -
Chikungunya and dengue fever among hospitalized febrile patients in northern Tanzania.
(Am J Trop Med Hyg, 2012-01)Consecutive febrile admissions were enrolled at two hospitals in Moshi, Tanzania. Confirmed acute Chikungunya virus (CHIKV), Dengue virus (DENV), and flavivirus infection were defined as a positive polymerase chain reaction ... -
Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages.
(Cell host & microbe, 2018-11)Zika virus (ZIKV), which emerged in regions endemic to dengue virus (DENV), is vertically transmitted and results in adverse pregnancy outcomes. Antibodies to DENV can cross-react with ZIKV, but whether these antibodies ... -
Dengue Virus Host Factors
(2009)Dengue fever and dengue hemorrhagic fever are estimated to afflict 50-100 million people annually and are caused by one of the four serotypes of dengue virus. Dengue virus is carried and transmitted to humans by mosquitoes ... -
Detection of Dengue, Chikungunya, and Zika Viruses Among Patients in Sarawak, Malaysia by a Novel Multiplexing Platform
(2019)Introduction: According to the World Health Organization (WHO), 500 million arbovirus cases are diagnosed around the world annually, with 2.7 million associated deaths [1]. The burden of disease caused by dengue, chikungunya, ... -
Distribution of Aedes mosquitoes in the Kilimanjaro Region of northern Tanzania.
(Pathog Glob Health, 2016-05)Little is known about the presence and distribution of Aedes mosquitoes in northern Tanzania despite the occurence of viruses transmitted by these mosquitoes such as Chikungunya virus (CHIKV) and Dengue virus (DENV) in the ... -
Drug Development in Dengue Virus and Molecular Epidemiology of Malaria in Western Kenya
(2017)Dengue viruses (DENV) and other mosquito-borne flaviviruses are rapidly emerging human pathogens that threaten nearly half of the world’s population. There is currently no effective vaccine or antiviral therapeutics for ... -
Minimal within-host dengue models highlight the specific roles of the immune response in primary and secondary dengue infections.
(J R Soc Interface, 2015-02-06)In recent years, the within-host viral dynamics of dengue infections have been increasingly characterized, and the relationship between aspects of these dynamics and the manifestation of severe disease has been increasingly ... -
Molecular and Epidemiological Assessment of Dengue Fever in Southern Sri Lanka in 2012
(2014)The mosquito-borne dengue viruses (DENV 1, 2, 3, and 4) have a rapidly expanding geographic range and have become endemic in over 100 countries with tropical and subtropical climates, including Sri Lanka. In Sri Lanka, dengue ... -
Phylodynamic Methods for Infectious Disease Epidemiology
(2014)In this dissertation, I present a general statistical framework for phylodynamic inference that can be used to estimate epidemiological parameters and reconstruct disease dynamics from pathogen genealogies. This framework ... -
Reconciling phylodynamics with epidemiology: the case of dengue virus in southern Vietnam.
(Mol Biol Evol, 2014-02)Coalescent methods are widely used to infer the demographic history of populations from gene genealogies. These approaches-often referred to as phylodynamic methods-have proven especially useful for reconstructing the dynamics ... -
Ribosomal Proteins RPLP1 and RPLP2 are Host Factors Critically Required for Flavivirus Infectivity by Promoting Efficient Viral Translation Elongation.
(2018)The Flavivirus genus contains several arthropod-borne viruses that pose global health threats, including dengue virus (DENV). We identified two ribosomal proteins, RPLP1 and RPLP2 (RPLP1/2), that are crucial host factors ...
