Browsing by Subject "Developmental biology"
Now showing items 1-20 of 89
-
A Clonal Analysis of Zebrafish Heart Morphogenesis and Regeneration
(2014)As vertebrate embryos grow and develop into adults, their organs must acquire mass and mature tissue architecture to maintain proper homeostasis. While juvenile growth encompasses a significant portion of life, relatively ... -
A Systems Level Analysis of Temperature-Dependent Sex Determination in the Red-Eared Slider Turtle Trachemys Scripta Elegans.
(2016)Sex determination is a critical biological process for all sexually reproducing animals. Despite its significance, evolution has provided a vast array of mechanisms by which sexual phenotype is determined and elaborated ... -
A Systems-Level Analysis of an Epithelial to Mesenchymal Transition
(2012)Embryonic development occurs with precisely timed morphogenetic cell movements directed by complex gene regulation. In this orchestrated series of events, some epithelial cells undergo extensive changes to become free moving ... -
Abl Family Kinases Regulate Endothelial Function
(2013)The vasculature has a crucial function in normal physiology, enabling the transport of oxygen and nutrients to cells throughout the body. In turn, endothelial cells, which form the inner-most lining of blood vessels, are ... -
Amino acid transporters regulate bone formation
(2021)Bone development and homeostasis are governed by a number of developmental signals, transcription factors and cellular metabolism. This process is also dependent on the orchestration of multiple cell types including osteoblasts, ... -
Analysis of <italic>crinkled</italic> Function in <italic>Drosophila melanogaster</italic> Hair and Bristle Morphogenesis
(2012)Mutations in myosin VIIa (MyoVIIa), an unconventional myosin, have been shown to cause Usher Syndrome Type 1B in humans. Usher Syndrome Type 1B is characterized by congenital sensorineural deafness, vestibular dysfunction ... -
Aneuploidy Tolerance in a Polyploid Organ
(2016)Endopolyploid cells (hereafter - polyploid cells), which contain whole genome duplications in an otherwise diploid organism, play vital roles in development and physiology of diverse organs such as our heart and liver. Polyploidy ... -
Basement Membranes Link Together and Stretch to Withstand Mechanical Forces
(2022)Basement membranes (BMs) are thin, dense sheets of extracellular matrix that surround most animal tissues and provide structural support. While the role of BMs in the structural support of tissues is well established, how ... -
Cell Fate Specification and the Regulation of RNA-dependent DNA Methylation in the Arabidopsis Root Meristem
(2016)The Arabidopsis root apical meristem (RAM) is a complex tissue capable of generating all the cell types that ultimately make up the root. The work presented in this thesis takes advantage of the versatility of high-throughput ... -
Cell Lineage Specification during Mouse Embryonic Gonad Development
(2017)The mouse embryonic gonad provides an outstanding model to study the complex mechanisms involved in cell fate specification and maintenance. At the bipotential stage, both XX and XY gonads are capable of becoming testes ... -
Cell Type Specification and Evolution of the Developing Sea Urchin Nervous and Digestive Systems
(2018)Multicellular organisms can be made up of hundreds of different cell types, each with their own unique morphology and characteristics to carry out their specific functions. For over 100 years, the sea urchin embryo has been ... -
Cellular and Molecular Mechanisms of Cardiac Chamber Maturation in Zebrafish
(2018)The formation of the heart is a critical part of development that, if defective, can lead to congenital malformations incompatible with life. An improved understanding of the cellular and molecular processes that build the ... -
Characterization of Basal Endfeet Reveals Roles for Local Gene Regulation in Radial Glia and Cortical Development
(2023)Radial glial cells (RGCs) are essential for the generation and organization of neurons in the cerebral cortex. RGCs have an elongated bipolar morphology with basal and apical endfeet that reside in distinct niches. Yet, ... -
Clonal Analysis of the Zebrafish Fin Regeneration Blastema
(2016)Regeneration is a remarkable feat of developmental regrowth and patterning. The blastema is a mass of progenitor cells that enables complete regeneration of amputated salamander limbs or fish fins. Despite years of study, ... -
Codon Usage Biases Differ Between Tissues and Can Confer Tissue-Specific Gene Expression in Drosophila
(2022)Codon usage bias is a fundamental aspect of the genetic code. For many years synonymous mutations to a coding sequence were considered to be functionally “silent.” We now appreciate that is not the case and that synonymous ... -
Consequences of Extended Early-Life Starvation in Adult Caenorhabditis elegans
(2021)The roundworm C. elegans reversibly arrests larval development during starvation, but extended early-life starvation reduces reproductive success. Maternal dietary restriction (DR) buffers progeny from starvation as young ... -
Developmental Programming of Brain and Behavior: A Role for the Innate Immune System of the Placenta and Brain?
(2015)The field of "perinatal programming" has increasingly implicated an adverse early-life environment in the etiology of many chronic health problems and mental disorders. The following dissertation research is based on the ... -
Developmental Regulation of Injury-Induced Cell Cycles in the Drosophila Hindgut
(2020)As development progresses, many tissues lose their ability to regenerate via cellular proliferation. In some tissues, including the human heart and kidneys, injury activates a non-proliferative cellular response known as ... -
Developmental Single-Cell RNA Sequencing in the Sea Urchin Species Lytechinus variegatus and Heliocidaris erythrogramma
(2022)The process by which a single cell develops into a complex multicellular organism with specified cell types and well-defined cellular roles is not completely understood, and the evolution of that process is even more enigmatic. ... -
Developmental Strategy for Generating Sensory Neuron Diversity
(2015)Sensory neuron diversity is a common theme in the animal kingdom. It provides the cellular infrastructure that supports the accurate perception of the external world. Among all sensory systems, the olfactory system demonstrates ...
