Browsing by Subject "Drosophila"
Now showing items 1-20 of 41
-
A mitotic DNA damage response requiring FANCD2 enables mitosis with broken DNA
(2017)In order to maintain genome integrity cells employ a set of well conserved DNA damage checkpoints. DNA damage checkpoints are active during interphase and serve to prevent mitosis with broken DNA. Mitosis with broken DNA ... -
A Novel Approach for Effective Dose Measurements in Dual-Energy
(2014)<bold>Purpose:</bold>Our goal was to test a novel concept approximating organ dose measurements using the single mean energy of the two sources in dual-energy (DE) CT environment. Therefore, the purpose of this study was ... -
Activity in descending dopaminergic neurons represents but is not required for leg movements in the fruit fly Drosophila.
(Physiol Rep, 2015-03)Modulatory descending neurons (DNs) that link the brain to body motor circuits, including dopaminergic DNs (DA-DNs), are thought to contribute to the flexible control of behavior. Dopamine elicits locomotor-like outputs ... -
Analysis of the Drosophila Sugar Receptor Genes
(2009)Gustation, also known as taste perception, is critical for the survival of most animal species. The fruit fly Drosophila melanogaster employs 68 different gustatory receptors (GRs) for the detection of sugars, bitter or ... -
Aneuploidy Tolerance in a Polyploid Organ
(2016)Endopolyploid cells (hereafter - polyploid cells), which contain whole genome duplications in an otherwise diploid organism, play vital roles in development and physiology of diverse organs such as our heart and liver. Polyploidy ... -
Causes and Consequences of Recombination Rate Variation in Drosophila
(2011)Recombination occurs during meiosis to produce new allelic combinations in natural populations, and thus strongly affects evolutionary processes. The model system Drosophila has been crucial for understanding the mechanics ... -
Characterization of Drosophila Ctr1a: New Roles for Ctr1 Proteins and Copper in Physiology and Cell Signaling Pathways
(2008-10-21)Copper is an essential trace element required by all aerobic organisms as a co-factor for enzymes involved in normal growth, development and physiology. Ctr1 proteins are members of a highly conserved family of copper importers ... -
Chromatin-based Reprogramming of Courtship Regulators With Social Experience
(2021)Organisms are presented with a wide variety of environmental stimuli and must interpret and respond to these cues in to perform a wide variety of behaviors, such as foraging, mating, fleeing, and fighting. The ability of ... -
Circuit and Behavioral Basis of Egg-Laying Site Selection in Drosophila melanogaster
(2015)One of the outstanding goals of neuroscience is to understand how neural circuits are assembled to produce context appropriate behavior. In an ever changing environment, it is critical for animals to be able to flexibly ... -
Cysteine proteinase-1 and cut protein isoform control dendritic innervation of two distinct sensory fields by a single neuron.
(Cell Rep, 2014-03-13)Dendrites often exhibit structural changes in response to local inputs. Although mechanisms that pattern and maintain dendritic arbors are becoming clearer, processes regulating regrowth, during context-dependent plasticity ... -
Dengue Virus Host Factors
(2009)Dengue fever and dengue hemorrhagic fever are estimated to afflict 50-100 million people annually and are caused by one of the four serotypes of dengue virus. Dengue virus is carried and transmitted to humans by mosquitoes ... -
Descending Control of Limb Movements in Drosophila melanogaster
(2016)Because the interactions between feedforward influences are inextricably linked during many motor outputs (including but not limited to walking), the contribution of descending inputs to the generation of movements is difficult ... -
Developmental Strategy for Generating Sensory Neuron Diversity
(2015)Sensory neuron diversity is a common theme in the animal kingdom. It provides the cellular infrastructure that supports the accurate perception of the external world. Among all sensory systems, the olfactory system demonstrates ... -
Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.
(G3 (Bethesda, Md.), 2015-03-04)The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution ... -
Epistasis among Drosophila persimilis factors conferring hybrid male sterility with D. pseudoobscura bogotana.
(PLoS One, 2010-10-27)The Bateson-Dobzhansky-Muller model posits that hybrid incompatibilities result from genetic changes that accumulate during population divergence. Indeed, much effort in recent years has been devoted to identifying genes ... -
Examination of Endogenous Rotund Expression and Function in Developing Drosophila Olfactory System Using CRISPR-Cas9-Mediated Protein Tagging.
(G3 (Bethesda), 2015-10-23)The zinc-finger protein Rotund (Rn) plays a critical role in controlling the development of the fly olfactory system. However, little is known about its molecular function in vivo. Here, we added protein tags to the rn locus ... -
Expression in aneuploid Drosophila S2 cells.
(PLoS Biol, 2010-02-23)Extensive departures from balanced gene dose in aneuploids are highly deleterious. However, we know very little about the relationship between gene copy number and expression in aneuploid cells. We determined copy number ... -
Gene expression disruptions of organism versus organ in Drosophila species hybrids.
(PLoS One, 2008-08-20)Hybrid dysfunctions, such as sterility, may result in part from disruptions in the regulation of gene expression. Studies of hybrids within the Drosophila simulans clade have reported genes expressed above or below the expression ... -
Genetic Analysis of the Contribution of Ion Channels to "Drosophila" Nociception
(2012)<p>Nociceptors are specialized primary sensory neurons that represent the first line of defense against potentially tissue damaging environmental stimuli, and are involved in pathological pain states caused by nerve damage, ... -
Genetic Dissection of the Biological and Molecular Role of IDH1 Mutations in Glioma
(2012)Gliomas are tumors of the central nervous system for which improvements in treatment are critically needed. Mutations in IDH1 and IDH2, which encode the cytosolic and mitochondrial NADP+-dependent isocitrate dehydrogenases, ...
