Browsing by Subject "Drosophila melanogaster"
Now showing items 1-20 of 26
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A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity.
(PLoS Genet, 2016-01)Sensory neuron diversity is required for organisms to decipher complex environmental cues. In Drosophila, the olfactory environment is detected by 50 different olfactory receptor neuron (ORN) classes that are clustered in ... -
A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis.
(G3 (Bethesda, Md.), 2016-08)Multiple aspects of Drosophila oogenesis, including germline stem cell activity, germ cell differentiation, and follicle survival, are regulated by the steroid hormone ecdysone. While the transcriptional targets of ecdysone ... -
A genome-wide RNAi screen reveals multiple regulators of caspase activation.
(The Journal of cell biology, 2007-11-12)Apoptosis is an evolutionally conserved cellular suicide mechanism that can be activated in response to a variety of stressful stimuli. Increasing evidence suggests that apoptotic regulation relies on specialized cell death ... -
A kinesin motor in a force-producing conformation.
(BMC Struct Biol, 2010-07-05)BACKGROUND: Kinesin motors hydrolyze ATP to produce force and move along microtubules, converting chemical energy into work by a mechanism that is only poorly understood. Key transitions and intermediate states in the process ... -
A paired-end sequencing strategy to map the complex landscape of transcription initiation.
(Nature methods, 2010-07)Recent studies using high-throughput sequencing protocols have uncovered the complexity of mammalian transcription by RNA polymerase II, helping to define several initiation patterns in which transcription start sites (TSSs) ... -
An entirely cell-based system to generate single-chain antibodies against cell surface receptors.
(2008)The generation of recombinant antibodies (Abs) using phage display is a proven method to obtain a large variety of Abs that bind with high affinity to a given antigen (Ag). Traditionally, the generation of single chain Abs ... -
Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm).
(J Cell Sci, 2005-05-01)Studies in a wide variety of organisms have produced a general model for the induction of apoptosis in which multiple signaling pathways lead ultimately to activation of the caspase family of proteases. Once activated, these ... -
Automatic annotation of spatial expression patterns via sparse Bayesian factor models.
(PLoS Comput Biol, 2011-07)Advances in reporters for gene expression have made it possible to document and quantify expression patterns in 2D-4D. In contrast to microarrays, which provide data for many genes but averaged and/or at low resolution, ... -
Chromatin Modulatory Proteins and Olfactory Receptor Signaling in the Refinement and Maintenance of Fruitless Expression in Olfactory Receptor Neurons.
(PLoS Biol, 2016-04)During development, sensory neurons must choose identities that allow them to detect specific signals and connect with appropriate target neurons. Ultimately, these sensory neurons will successfully integrate into appropriate ... -
Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation.
(J Cell Sci, 2010-07-01)Wg/Wnt signals specify cell fates in both invertebrate and vertebrate embryos and maintain stem-cell populations in many adult tissues. Deregulation of the Wnt pathway can transform cells to a proliferative fate, leading ... -
Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.
(G3 (Bethesda, Md.), 2015-03-04)The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution ... -
Galactokinase is a Novel Modifier of Calcineurin-Induced Cardiomyopathy in Drosophila
(2014)Calcineurin is both necessary and sufficient to induce cardiac hypertrophy, an independent risk factor for arrhythmia, dilated cardiomyopathy, heart failure, and sudden cardiac death. However, current knowledge of the downstream ... -
speck, First Identified in Drosophila melanogaster in 1910, Is Encoded by the Arylalkalamine N-Acetyltransferase (AANAT1) Gene.
(G3 (Bethesda, Md.), 2020-09-02)The pigmentation mutation speck is a commonly used recombination marker characterized by a darkly pigmented region at the wing hinge. Identified in 1910 by Thomas Hunt Morgan, speck was characterized by Sturtevant as the ... -
Long-duration animal tracking in difficult lighting conditions.
(Sci Rep, 2015-07-01)High-throughput analysis of animal behavior requires software to analyze videos. Such software typically depends on the experiments' being performed in good lighting conditions, but this ideal is difficult or impossible ... -
Mapping the complexity of transcription control in higher eukaryotes.
(Genome Biol, 2010)Recent genomic analyses suggest the importance of combinatorial regulation by broadly expressed transcription factors rather than expression domains characterized by highly specific factors. -
Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death.
(Cell Death Differ, 2011-10)In most multicellular organisms, the decision to undergo programmed cell death in response to cellular damage or developmental cues is typically transmitted through mitochondria. It has been suggested that an exception is ... -
Modeling the evolution of regulatory elements by simultaneous detection and alignment with phylogenetic pair HMMs.
(PLoS Comput Biol, 2010-12-16)The computational detection of regulatory elements in DNA is a difficult but important problem impacting our progress in understanding the complex nature of eukaryotic gene regulation. Attempts to utilize cross-species ... -
Mutation accumulation may be a minor force in shaping life history traits.
(PLoS One, 2012)Is senescence the adaptive result of tradeoffs between younger and older ages or the nonadaptive burden of deleterious mutations that act at older ages? To shed new light on this unresolved question we combine adaptive and ... -
Nociceptor-Enriched Genes Required for Normal Thermal Nociception.
(Cell reports, 2016-07)Here, we describe a targeted reverse genetic screen for thermal nociception genes in Drosophila larvae. Using laser capture microdissection and microarray analyses of nociceptive and non-nociceptive neurons, we identified ... -
Novel Features of Drosophila Sweet Taste System
(2019)The sense of taste enables animal survival and reproduction by allowing them to detect and discriminate different chemosensory stimuli so as to select for food options that are suitable for ingestion for both themselves ...
