Browsing by Subject "Drug delivery"
Now showing items 1-7 of 7
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Bioorthogonal Functionalization of Elastin-like Polypeptides
(2019)Recombinant technology has given us the powerful ability to imagine and create novel biological entities, from potent therapeutics to functionally active materials. By harnessing nature’s building blocks and reconfiguring ... -
Controlled Release Systems for Treating Type 2 Diabetes and Their Application Toward Multi-Agonist Combination Therapies
(2019)Over 30 million people in the United States suffer from type 2 diabetes (T2D), and this figure is rapidly increasing. Currently available glucose-lowering drugs largely treat the symptoms of diabetes and not the underlying ... -
Development of an Injectable Ablative Therapy for Resource-Limited Settings: Applications in Tumor Ablation
(2020)Although two-thirds of the global cancer mortality burden is predicted to occur in low- and middle-income countries (LMICs), citizens of these countries have disproportionately less access to resources and facilities to ... -
Genetically Encoded Albumin Binding Drug Delivery Systems
(2018)Albumin is emerging as a promising and versatile carrier to improve the pharmacokinetic and therapeutic profiles of drugs because of its unique physiological properties. The objective of this dissertation is to develop drug ... -
Integrating Protein Engineering and Genomics for Cancer Therapy
(2018)We have developed a broadly applicable platform that harnesses the power of protein engineering and genetic screening to produce efficacious protein-drug combinations for cancer therapy. For proof-of-concept, we implemented ... -
Recombinantly Engineered Polypeptides for Drug Delivery
(2017)Novel drug delivery methods aims to improve the therapeutic efficacy by enhancing the molecule’s pharmacokinetic profile as well as increasing its accumulation at the target size while reducing the amount at off-target sites. ... -
Reduction of HIV-virion Transport for Prevention of HIV Transmission
(2010)This dissertation explores strategies for reducing HIV-virion transport to mucosal surfaces to prevent HIV infection. Infection requires contact between HIV and an infectable cell, so any means of inhibiting this step could ...
