Browsing by Subject "Engineering, Biomedical"
Now showing items 1-20 of 72
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A Discrete Monolayer Cardiac Tissue Model for Tissue Preparation Specific Modeling
(2010)Engineered monolayers created by using microabrasion and micropatterning methods have provided a simplified in vitro system to study the effects of anisotropy and fiber direction on electrical propagation. Interpreting the ... -
A Study of Extracting Information from Neuronal Ensemble Activity and Sending Information to the Brain Using Microstimulation in Two Experimental Models: Bipedal Locomotion in Rhesus Macaques and Instructed Reaching Movements in Owl Monkeys
(2009)The loss of the ability to walk as the result of neurological injury or disease critically impacts the mobility and everyday lifestyle of millions. The World Heath Organization (WHO) estimates that approximately 1% of the ... -
Accuracy and Patient Dose in Neutron Stimulated Emission Computed Tomography for Diagnosis of Liver Iron Overload: Simulations in GEANT4
(2007-08-13)Neutron stimulated emission computed tomography (NSECT) is being proposed as an experimental technique to diagnose iron overload in patients. Proof-of-concept experiments have suggested that NSECT may have potential to make ... -
Acoustic Radiation Force Impulse Imaging of Myocardial Performance
(2009)Cardiovascular disease is the leading cause of death for developed countries, including the United States. In order to diagnose and detect certain cardiac diseases, it is necessary to assess myocardial performance and function. ... -
Acoustic Radiation Force Impulse-Driven Shear Wave Velocimetry in Cardiac Tissue
(2010)Acoustic radiation force impulses (ARFI) have been used to generated transverse-traveling mechanical waves in various biological tissues. The velocity of these waves is related to a medium's stiffness and thus can offer ... -
Active Staining for In Vivo Magnetic Resonance Microscopy of the Mouse Brain
(2009)Mice have become the preferred model system for studying brain function and disease. With the powerful genetic tools available, mouse models can be created to study the underlying molecular basis of neurobiology in vivo. ... -
Adipose Stem Cells Improve the Foreign Body Response
(2008-03-18)Many implanted devices fail due to the formation of an avascular capsule. Fat is known to promote healing and vascularization. It is possible that isolating and attaching ASCs (adipose stem cells) to an implanted device ... -
Advanced Fibrous Scaffold Engineering for Controlled Delivery and Regenerative Medicine Applications
(2010)Continuous nanostructures, such as electrospun nanofibers, embedded with proteins may synergistically present the topographical and biochemical signals to cells for tissue engineering applications. In this dissertation, ... -
Affinity-Modulation Drug Delivery Using Thermosensitive Elastin-Like Polypeptide Block Copolymers
(2010)Antivascular targeting is a promising strategy for tumor therapy. This strategy overcomes many of the transport barriers and has shown efficacy in many preclinical models, but targeting epitopes on tumor vasculature can ... -
An in Vitro Study of Cellular Cardiomyoplasty: Structural and Functional Interactions of Non-cardiomyocytes and Cardiomyocytes
(2007-08-21)A better understanding of structural and functional interactions between cardiac and non-cardiac cells is essential to better address the sequelae of cardiac disease and improve the potential cellular implantation therapies. ... -
Analysis and Design of Electrodes for Deep Brain Stimulation
(2009)Deep brain stimulation (DBS) electrodes are intended to stimulate specific areas of the brain to treat movement disorders including essential tremor, Parkinson's disease and dystonia. An important goal in the design of next ... -
Analyzing the Mechanisms of Action of Thalamic Deep Brain Stimulation: Computational and Clinical Studies
(2009)Deep brain stimulation (DBS) is an established treatment for movement disorders that has been implanted in more than 40,000 patients worldwide. Despite the successes of DBS, its mechanisms of action are not well understood. ... -
Association of pre-treatment radiomic features with lung cancer recurrence following stereotactic body radiation therapy.
(Physics in medicine and biology, 2019-01-08)The purpose of this work was to investigate the potential relationship between radiomic features extracted from pre-treatment x-ray CT images and clinical outcomes following stereotactic body radiation therapy (SBRT) for ... -
Bayesian Analysis and Computational Methods for Dynamic Modeling
(2009)Dynamic models, also termed state space models, comprise an extremely rich model class for time series analysis. This dissertation focuses on building state space models for a variety of contexts and computationally efficient ... -
Biomimetic Composite Scaffolds for the Functional Tissue Engineering of Articular Cartilage
(2009)Articular cartilage is the connective tissue that lines the ends of long bones in diarthrodial joints, providing a low-friction load-bearing surface that can withstand a lifetime of loading cycles under normal conditions. ... -
Bistability, Synthetic Biology, and Antibiotic Treatment
(2010)Bistable switches are commonly observed in the regulation of critical processes such as cell cycles and differentiation. The switches possess two fundamental properties: memory and bimodality. Once switched ON, the switches ... -
Characterization and Modeling of Fluctuating Hypoxia in Breast Cancer
(2008-08-08)Tumor hypoxia is an enduring problem for traditional cancer therapies such as radiation and chemotherapy. This obstacle has traditionally been attributed to the widespread presence of chronic, diffusion-limited hypoxia ... -
Computational Molecular Engineering Nucleic Acid Binding Proteins and Enzymes
(2010)Interactions between nucleic acid substrates and the proteins and enzymes that bind and catalyze them are ubiquitous and essential for reading, writing, replicating, repairing, and regulating the genomic code by the proteomic ... -
Computer Aided Detection of Masses in Breast Tomosynthesis Imaging Using Information Theory Principles
(2008-09-18)Breast cancer screening is currently performed by mammography, which is limited by overlying anatomy and dense breast tissue. Computer aided detection (CADe) systems can serve as a double reader to improve radiologist ... -
Control of Bladder Function by Electrical Stimulation of Pudendal Afferents
(2010)Spinal cord injury (SCI) and other neurological diseases and disorders can cause urinary dysfunction that can cause serious health problems and reduce an individual's quality of life. Current methods for treating urinary ...
