Browsing by Subject "Environmental Exposure"

Now showing items 1-16 of 16

    • A translatable predictor of human radiation exposure. 

      Lucas, Joseph; Dressman, Holly K; Suchindran, Sunil; Nakamura, Mai; Chao, Nelson J; Himburg, Heather; Minor, Kerry; ... (12 authors) (PLoS One, 2014)
      Terrorism using radiological dirty bombs or improvised nuclear devices is recognized as a major threat to both public health and national security. In the event of a radiological or nuclear disaster, rapid and accurate ...

    • Additional perspectives on chronic kidney disease of unknown aetiology (CKDu) in Sri Lanka--lessons learned from the WHO CKDu population prevalence study. 

      Redmon, Jennifer Hoponick; Elledge, Myles F; Womack, Donna S; Wickremashinghe, Rajitha; Wanigasuriya, Kamani P; Peiris-John, Roshini J; Lunyera, Joseph; ... (10 authors) (BMC Nephrol, 2014-07-28)
      The recent emergence of an apparently new form of chronic kidney disease of unknown aetiology (CKDu) has become a serious public health crisis in Sri Lanka. CKDu is slowly progressive, irreversible, and asymptomatic until ...

    • Early hematopoiesis inhibition under chronic radiation exposure in humans. 

      Akleyev, Alexander V; Akushevich, Igor V; Dimov, Georgy P; Veremeyeva, Galina A; Varfolomeyeva, Tatyana A; Ukraintseva, Svetlana V; Yashin, Anatoly I (Radiat Environ Biophys, 2010-05)
      The major goal of this study was to identify and quantitatively describe the association between the characteristics of chronic (low-dose rate) exposure to (low LET) ionizing radiation and cellularity of peripheral blood ...

    • Early hematopoietic effects of chronic radiation exposure in humans. 

      Akleyev, Alexander V; Akushevich, Igor V; Dimov, Georgy P; Veremeyeva, Galina A; Varfolomeyeva, Tatyana A; Ukraintseva, Svetlana V; Yashin, Anatoly I (Health Phys, 2010-09)
      The major goal of this study is to investigate and quantitatively describe the nature of the relationship between the characteristics of chronic exposure to ionizing radiation and specific patterns of hematopoiesis reduction. ...

    • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 

      Chao, Nelson J; Chute, JP; Dressman, HK; Ginsburg, Geoffrey Steven; Himburg, Heather; Meadows, Sarah K; Muramoto, Garrett G; ... (10 authors) (PLoS One, 2008-04-02)
      BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. METHODS AND FINDINGS: We have sought to determine the ...

    • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 

      Meadows, Sarah K; Dressman, Holly K; Muramoto, Garrett G; Himburg, Heather; Salter, Alice; Wei, ZhengZheng; Ginsburg, Geoffrey S; ... (10 authors) (PLoS One, 2008-04-02)
      BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. METHODS AND FINDINGS: We have sought to determine the ...

    • Gene expression signatures that predict radiation exposure in mice and humans. 

      Dressman, Holly K; Muramoto, Garrett G; Chao, Nelson J; Meadows, Sarah; Marshall, Dawn; Ginsburg, Geoffrey S; Nevins, Joseph R; ... (8 authors) (PLoS Med, 2007-04)
      BACKGROUND: The capacity to assess environmental inputs to biological phenotypes is limited by methods that can accurately and quantitatively measure these contributions. One such example can be seen in the context of exposure ...

    • Global air quality and health co-benefits of mitigating near-term climate change through methane and black carbon emission controls. 

      Anenberg, Susan C; Schwartz, Joel; Shindell, Drew; Amann, Markus; Faluvegi, Greg; Klimont, Zbigniew; Janssens-Maenhout, Greet; ... (19 authors) (Environ Health Perspect, 2012-06)
      BACKGROUND: Tropospheric ozone and black carbon (BC), a component of fine particulate matter (PM ≤ 2.5 µm in aerodynamic diameter; PM(2.5)), are associated with premature mortality and they disrupt global and regional climate. ...

    • Methodologic and statistical approaches to studying human fertility and environmental exposure. 

      Tingen, Candace; Stanford, Joseph B; Dunson, David B (Environ Health Perspect, 2004-01)
      Although there has been growing concern about the effects of environmental exposures on human fertility, standard epidemiologic study designs may not collect sufficient data to identify subtle effects while properly adjusting ...

    • Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts. 

      Akushevich, Igor V; Veremeyeva, Galina A; Dimov, Georgy P; Ukraintseva, Svetlana V; Arbeev, Konstantin G; Akleyev, Alexander V; Yashin, Anatoly I (Health Phys, 2010-09)
      A new model of the hematopoietic system for humans chronically exposed to ionizing radiation allows for quantitative description of the initial hematopoiesis inhibition and subsequent increase in the risks of late stochastic ...

    • Newborns of obese parents have altered DNA methylation patterns at imprinted genes. 

      Soubry, A; Murphy, SK; Wang, F; Huang, Z; Vidal, AC; Fuemmeler, BF; Kurtzberg, J; ... (11 authors) (International journal of obesity (2005), 2015-04)
      Several epidemiologic studies have demonstrated associations between periconceptional environmental exposures and health status of the offspring in later life. Although these environmentally related effects have been attributed ...

    • On the interplay of telomeres, nevi and the risk of melanoma. 

      Bodelon, Clara; Pfeiffer, Ruth M; Bollati, Valentina; Debbache, Julien; Calista, Donato; Ghiorzo, Paola; Fargnoli, Maria Concetta; ... (22 authors) (PloS one, 2012-01)
      The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres have been found to be associated with many cancers and with number of nevi, a known risk factor for melanoma. However, shorter telomeres ...

    • Reduction in urinary arsenic levels in response to arsenic mitigation efforts in Araihazar, Bangladesh. 

      Chen, Yu; van Geen, Alexander; Graziano, Joseph H; Pfaff, Alexander; Madajewicz, Malgosia; Parvez, Faruque; Hussain, AZM Iftekhar; ... (10 authors) (Environ Health Perspect, 2007-06)
      BACKGROUND: There is a need to identify and evaluate an effective mitigation program for arsenic exposure from drinking water in Bangladesh. OBJECTIVE: We evaluated the effectiveness of a multifaceted mitigation program ...

    • Residential metal contamination and potential health risks of exposure in adobe brick houses in Potosí, Bolivia. 

      McEwen, Abigail R; Hsu-Kim, Heileen; Robins, Nicholas A; Hagan, Nicole A; Halabi, Susan; Barras, Olivo; Richter, Daniel deB; ... (8 authors) (The Science of the total environment, 2016-08)
      Potosí, Bolivia, is the site of centuries of historic and present-day mining of the Cerro Rico, a mountain known for its rich polymetallic deposits, and was the site of large-scale Colonial era silver refining operations. ...

    • Studying human fertility and environmental exposures. 

      Slama, Rémy; Ducot, Béatrice; Keiding, Niels; Bouyer, Jean (Environ Health Perspect, 2004-08)

    • The toxicology of climate change: environmental contaminants in a warming world. 

      Noyes, Pamela D; McElwee, Matthew K; Miller, Hilary D; Clark, Bryan W; Van Tiem, Lindsey A; Walcott, Kia C; Erwin, Kyle N; ... (8 authors) (Environ Int, 2009-08)
      Climate change induced by anthropogenic warming of the earth's atmosphere is a daunting problem. This review examines one of the consequences of climate change that has only recently attracted attention: namely, the effects ...