Browsing by Subject "Environmental Exposure"
Now showing items 1-20 of 24
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A translatable predictor of human radiation exposure.
(PLoS One, 2014)Terrorism using radiological dirty bombs or improvised nuclear devices is recognized as a major threat to both public health and national security. In the event of a radiological or nuclear disaster, rapid and accurate ... -
Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.
(Aging, 2020-12)<h4>Background</h4>Accelerated epigenetic age has been proposed as a biomarker of increased aging, which may indicate disruptions in cellular and organ system homeostasis and thus contribute to sensitivity to environmental ... -
Additional perspectives on chronic kidney disease of unknown aetiology (CKDu) in Sri Lanka--lessons learned from the WHO CKDu population prevalence study.
(BMC Nephrol, 2014-07-28)The recent emergence of an apparently new form of chronic kidney disease of unknown aetiology (CKDu) has become a serious public health crisis in Sri Lanka. CKDu is slowly progressive, irreversible, and asymptomatic until ... -
An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment.
(Environmental health perspectives, 2005-08)Bisphenol A (BPA) is the monomer used to manufacture polycarbonate plastic, the resin lining of cans, and other products, with global capacity in excess of 6.4 billion lb/year. Because the ester bonds in these BPA-based ... -
Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease.
(Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020-06)The etiologic pathways leading to neuropsychiatric diseases remain poorly defined. As genomic technologies have advanced over the past several decades, considerable progress has been made linking neuropsychiatric disorders ... -
Controlled human exposures to ambient pollutant particles in susceptible populations.
(Environmental health : a global access science source, 2009-01)Epidemiologic studies have established an association between exposures to air pollution particles and human mortality and morbidity at concentrations of particles currently found in major metropolitan areas. The adverse ... -
Critical windows of exposure for children's health: the reproductive system in animals and humans.
(Environmental health perspectives, 2000-06)Drugs and environmental chemicals can adversely affect the reproductive system. Currently, available data indicate that the consequences of exposure depend on the nature of the chemical, its target, and the timing of exposure ... -
Early hematopoiesis inhibition under chronic radiation exposure in humans.
(Radiat Environ Biophys, 2010-05)The major goal of this study was to identify and quantitatively describe the association between the characteristics of chronic (low-dose rate) exposure to (low LET) ionizing radiation and cellularity of peripheral blood ... -
Early hematopoietic effects of chronic radiation exposure in humans.
(Health Phys, 2010-09)The major goal of this study is to investigate and quantitatively describe the nature of the relationship between the characteristics of chronic exposure to ionizing radiation and specific patterns of hematopoiesis reduction. ... -
Epithelial injury and interstitial fibrosis in the proximal alveolar regions of rats chronically exposed to a simulated pattern of urban ambient ozone.
(Toxicology and applied pharmacology, 1992-08)Electron microscopic morphometry was used to study the development of lung injury during and after chronic (78 weeks) exposure to a pattern of ozone (O3) designed to simulate high urban ambient concentrations that occur ... -
Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.
(PLoS One, 2008-04-02)BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. METHODS AND FINDINGS: We have sought to determine the ... -
Gene expression signatures that predict radiation exposure in mice and humans.
(PLoS Med, 2007-04)BACKGROUND: The capacity to assess environmental inputs to biological phenotypes is limited by methods that can accurately and quantitatively measure these contributions. One such example can be seen in the context of exposure ... -
Global air quality and health co-benefits of mitigating near-term climate change through methane and black carbon emission controls.
(Environ Health Perspect, 2012-06)BACKGROUND: Tropospheric ozone and black carbon (BC), a component of fine particulate matter (PM ≤ 2.5 µm in aerodynamic diameter; PM(2.5)), are associated with premature mortality and they disrupt global and regional climate. ... -
Heatwaves, medications, and heat-related hospitalization in older Medicare beneficiaries with chronic conditions.
(PloS one, 2020-01)<h4>Background</h4>Heatwaves kill more people than floods, tornadoes, and earthquakes combined and disproportionally affect older persons and those with chronic conditions. Commonly used medications for chronic conditions, ... -
Inflammatory Cytokines and White Blood Cell Counts Response to Environmental Levels of Diesel Exhaust and Ozone Inhalation Exposures.
(PloS one, 2016-01)Epidemiological observations of urban inhalation exposures to diesel exhaust (DE) and ozone (O3) have shown pre-clinical cardiopulmonary responses in humans. Identifying the key biological mechanisms that initiate these ... -
Mass-casualty victim "surge" management. Preparing for bombings and blast-related injuries with possibility of hazardous materials exposure.
(North Carolina medical journal, 2002-09)Bombings and other blast-related events place severe demands on pre-hospital and in-hospital systems. The resulting surge of victims can overwhelm the resources of any facility not prepared for such an event. The September ... -
Methodologic and statistical approaches to studying human fertility and environmental exposure.
(Environ Health Perspect, 2004-01)Although there has been growing concern about the effects of environmental exposures on human fertility, standard epidemiologic study designs may not collect sufficient data to identify subtle effects while properly adjusting ... -
Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts.
(Health Phys, 2010-09)A new model of the hematopoietic system for humans chronically exposed to ionizing radiation allows for quantitative description of the initial hematopoiesis inhibition and subsequent increase in the risks of late stochastic ... -
Newborns of obese parents have altered DNA methylation patterns at imprinted genes.
(International journal of obesity (2005), 2015-04)Several epidemiologic studies have demonstrated associations between periconceptional environmental exposures and health status of the offspring in later life. Although these environmentally related effects have been attributed ... -
On the interplay of telomeres, nevi and the risk of melanoma.
(PloS one, 2012-01)The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres have been found to be associated with many cancers and with number of nevi, a known risk factor for melanoma. However, shorter telomeres ...
