Browsing by Subject "Epigenetics"
Now showing items 1-20 of 20
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“Ceci n’est pas une pipe”: A Comparison of French and U.S. Health Research on the Neurodevelopmental and Epigenetic Effects of Tobacco Exposure on Vulnerable Populations
(2016-04-25)This thesis explores how cultural beliefs and practices influence biomedical research landscapes in two high resource cultural contexts, the US and the Euro-American francophone world. First, I examine how cultural mores ... -
Chromatin Determinants of the Eukaryotic DNA Replication Program
(2011)The accurate and timely replication of eukaryotic DNA during S-phase is of critical importance for the cell and for the inheritance of genetic information. Missteps in the replication program can activate cell cycle checkpoints ... -
Chromatin-based Reprogramming of Courtship Regulators With Social Experience
(2021)Organisms are presented with a wide variety of environmental stimuli and must interpret and respond to these cues in to perform a wide variety of behaviors, such as foraging, mating, fleeing, and fighting. The ability of ... -
Defining and Targeting Epigenetic Rewiring During Tumor Progression
(2019)Tumor recurrence following initial treatment is the leading cause of death among breast cancer patients. Epigenetic mechanisms are critical for regulation of gene expression and to facilitate appropriate responses ... -
Development and Application of Novel CRISPR-Based Epigenome Editors
(2020)The eukaryotic epigenome has an instrumental role in determining and maintaining cell identity and function. Epigenetic components such as DNA methylation, histone tail modifications, chromatin accessibility, and DNA architecture ... -
Epigenetic Profiling of Zebrafish Fin Regeneration
(2020)The ability to regenerate after injury is quite astonishing, yet not all organisms share this ability. Mammalian genomes likely encode all gene products required to regenerate an amputated limb, yet they lack the correct ... -
Epigenetics: A Paradigm Shift or Tweaking the Details?
(2015-05-12)*Designated as an Exemplary Master's Project for 2014-15* We know that our lifestyle choices and experiences can influence our health: the food we eat, the environment we live in, and the social relationships we form can ... -
Fluorescent Detection of Chromatin using Functionalized Magnetic Beads on a Digital Microfluidic Device
(2022)Epigenetics is the study of inheritable mechanisms and factors that regulate gene expression. Although the underlying genetic sequence is the same in every cell, it is the epigenome that controls the expression of these ... -
Functional and Therapeutic Relevance of MTAP Deletion in Glioblastoma
(2019)Primary glioblastoma (GBM) is the most common and lethal primary malignant brain tumor, with a median patient survival of only 15 months from the time of diagnosis. GBM is particularly challenging to treat due to its aggressive ... -
Genetic and Epigenetic Regulation of Starvation Resistance in Caenorhabditis elegans
(2021)Fluctuations in nutrient availability occur for nearly all species, and adaptation to endure starvation conditions is essential. Genetic pathways involved in regulating starvation resistance are implicated in aging and complex ... -
Genome-Wide Dynamics of Chromatin Maturation Following DNA Replication
(2018)All DNA-templated events, including replication and gene transcription, occur in the context of the local chromatin environment. The passage of the replication machinery results in disassembly of chromatin, which must be ... -
Identification of Novel Imprinted Domains in the Therian Lineage
(2010)Genomic imprinting is the parent-of-origin dependent monoallelic expression of select developmentally important genes that are regulated by epigenetic mechanisms. It is believed to have co-evolved with placentation in the ... -
Male obesity impacts DNA methylation reprogramming in sperm.
(Clinical epigenetics, 2021-01-25)<h4>Background</h4>Male obesity has profound effects on morbidity and mortality, but relatively little is known about the impact of obesity on gametes and the potential for adverse effects of male obesity to be passed to ... -
Postmitotic Dynamics in Chromatin Modification and Regulatory Topology Underlie Cerebellar Granule Maturation
(2023)Neurons are remarkably long-lived cells that are born early on in development and maintained over the lifespan of an organism. Their birth is followed by their iterative maturation into functional neurons that can participate ... -
Probing the Interfaces of Epigenetic Complexes: Efforts Towards Elucidating and Targeting Critical Protein:Protein and Protein:lncRNA Interactions of Lysine-Specific Demethylase 1 (KDM1A/LSD1)
(2019)The post translational modification (PTM) of histone proteins is a highly dynamic process that is utilized in the control of gene transcription. This epigenetic process involves enzymatic ‘writers’ and ‘erasers’ which place ... -
Stochastic Dynamics and Epigenetic Regulation of Gene Expression: from Stimulus Response to Evolutionary Adaptation
(2016)How organisms adapt and survive in continuously fluctuating environments is a central question of evolutionary biology. Additionally, organisms have to deal with the inherent stochasticity in all cellular processes. The ... -
The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease.
(Alzheimers Dement, 2017-02-24)It is hypothesized that retrotransposons have played a fundamental role in primate evolution and that enhanced neurologic retrotransposon activity in humans may underlie the origin of higher cognitive function. As a potential ... -
The Effects of Cannabis sativa on the Sperm Epigenome
(2021)We have a rudimentary understanding of the consequences of preconception exposure to cannabis. As the most commonly used illicit psychoactive drug, cannabis prevalence is rapidly increasing across the United States (US), ... -
The Role of Acetylation in the Metabolic Reprogramming of Cancer Cells
(2016)Identifying metabolic vulnerabilities of cancer cells remains a subject of investigation for the identification of potential metabolically based therapies for cancer. It is well known that proliferating cells become largely ... -
The Role of TET Proteins in the Epigenetic Regulation of Neural Gene Expression and Behavior
(2016)Understanding how genes affect behavior is critical to develop precise therapies for human behavioral disorders. The ability to investigate the relationship between genes and behavior has been greatly advanced over the last ...
