Now showing items 1-3 of 3

    • Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis. 

      PRISM Investigators; Rowan, Kathryn M; Angus, Derek C; Bailey, Michael; Barnato, Amber E; Bellomo, Rinaldo; Canter, Ruth R; ... (24 authors) (The New England journal of medicine, 2017-06)
      BACKGROUND:After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. ...
    • Nitric oxide loading reduces sickle red cell adhesion and vaso-occlusion in vivo. 

      McMahon, Timothy J; Shan, Siqing; Riccio, Daniel A; Batchvarova, Milena; Zhu, Hongmei; Telen, Marilyn J; Zennadi, Rahima (Blood advances, 2019-09)
      Sickle red blood cells (SSRBCs) are adherent to the endothelium, activate leukocyte adhesion, and are deficient in bioactive nitric oxide (NO) adducts such as S-nitrosothiols (SNOs), with reduced ability to induce vasodilation ...
    • Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes. 

      Rogers, Stephen C; Dosier, Laura B; McMahon, Timothy J; Zhu, Hongmei; Timm, David; Zhang, Hengtao; Herbert, Joseph; ... (24 authors) (PloS one, 2018-01)
      Intact red blood cells (RBCs) are required for phenotypic analyses. In order to allow separation (time and location) between subject encounter and sample analysis, we developed a research-specific RBC cryopreservation protocol ...