Browsing by Subject "Estrogens"
Now showing items 1-11 of 11
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Application of the estrogen threshold hypothesis to the physiologic hypoestrogenemia of lactation.
(Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 2015-03)OBJECTIVE: This study determined the impact of breastfeeding on hypoestrogenic symptoms among women in the postpartum period and correlated these findings with the Estrogen Threshold Hypothesis, which postulates that the ... -
Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology.
(Frontiers in immunology, 2022-01)Endometriosis is an estrogen dependent, chronic inflammatory disease characterized by the growth of endometrial lining outside of the uterus. Mast cells have emerged as key players in regulating not only allergic responses ... -
Hormonal management of menopausal symptoms in women with a history of gynecologic malignancy.
(Menopause (New York, N.Y.), 2020-02)<h4>Objective</h4>The aim of the study was to review the role of hormone therapy in menopausal patients with breast cancer and gynecologic malignancies.<h4>Methods</h4>We searched MEDLINE (via PubMed) using a combination ... -
Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study.
(BMC Med Genet, 2010-01-19)BACKGROUND: Several studies have noted that genetic variants of SCARB1, a lipoprotein receptor involved in reverse cholesterol transport, are associated with serum lipid levels in a sex-dependent fashion. However, the mechanism ... -
Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma.
(The Journal of clinical investigation, 2021-12)Immune checkpoint blockade (ICB) therapies have significantly prolonged patient survival across multiple tumor types, particularly in melanoma. Interestingly, sex-specific differences in response to ICB have been observed, ... -
Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models.
(The Journal of pathology, 2012-01)Squamous metaplasia (SQM) is a specific phenotype in response to oestrogen in the prostate and oestrogen receptor (ER) α is required to mediate this response. Previous studies utilizing tissue recombination with seminal ... -
Mitochondrial Quality Control as a Therapeutic Target.
(Pharmacol Rev, 2016-01)In addition to oxidative phosphorylation (OXPHOS), mitochondria perform other functions such as heme biosynthesis and oxygen sensing and mediate calcium homeostasis, cell growth, and cell death. They participate in cell ... -
Oestrogen shuts the door on SOX9.
(BMC Biol, 2010-08-31)Oestrogen exerts a robust yet imperfectly understood effect on sexual development in vertebrate embryos. New work by Pask and colleagues in BMC Biology indicates that it may interfere with male development by preventing ... -
Phytochemical mimicry of reproductive hormones and modulation of herbivore fertility by phytoestrogens.
(Environmental health perspectives, 1988-06)Plants have physical and chemical mechanisms for defense from attack by animals. Phytochemical defenses that protect plants from attack by insects include antifeedants, insecticides, and insect growth regulators. Phytochemical ... -
Progesterone Signaling in Endometrial Epithelial Organoids.
(Cells, 2022-05)For pregnancy to be established, uterine cells respond to the ovarian hormones, estrogen, and progesterone, via their nuclear receptors, the estrogen receptor (ESR1) and progesterone receptor (PGR). ESR1 and PGR regulate ... -
The Impact of Endometriosis across the Lifespan of Women: Foreseeable Research and Therapeutic Prospects.
(BioMed research international, 2015-01)In addition to estrogen dependence, endometriosis is characterized by chronic pelvic inflammation. The impact of the chronic pelvic inflammatory state on other organ systems and women's health is unclear. Endometriosis associated ...
