Browsing by Subject "FRET"
Now showing items 1-7 of 7
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BDNF-TrkB Signaling in Single-Spine Structural Plasticity
(2016)Multiple lines of evidence reveal that activation of the tropomyosin related kinase B (TrkB) receptor is a critical molecular mechanism underlying status epilepticus (SE) induced epilepsy development. However, the cellular ... -
Calcium/Calmodulin-Dependent Protein Kinase II Serves as a Biochemical Integrator of Calcium Signals for the Induction of Synaptic Plasticity
(2016)Repetitive Ca2+ transients in dendritic spines induce various forms of synaptic plasticity by transmitting information encoded in their frequency and amplitude. CaMKII plays a critical role in decoding these Ca2+ signals ... -
Development of a beta-Secretase Activated Prochelator and FRET Probe to Mediate Copper Toxicity in Alzheimer's Disease
(2012)Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects over 5 million people in the United States alone. This number is predicted to triple to by the year 2050 due to both increasing life expectancies ... -
Development of Tunable Molecular Tension Sensors to Visualize Vinculin Loading and Detect Mechanosensitive Protein Recruitment to Focal Adhesions
(2018)Mechanical forces are potent drivers of many biological processes. The form and function of many tissues depends on cells receiving the proper mechanical signals either from neighboring cells or from the underlying matrix. ... -
Mathematical Modeling and Experimental Verification of Resonance Energy Transfer Networks: Applications in Cryptography and Biological Sensing
(2014)FRET between pairs of fluorophores is widely used as a biological assay. However, the properties of larger fluorophore networks are poorly understood and their application space has not yet been fully explored. This dissertation ... -
Spatiotemporal Dynamics of CaMKI During Structural Plasticity of Single Dendritic Spines
(2016)Multifunctional calcium/calmodulin dependent protein kinases (CaMKs) are key regulators of spine structural plasticity and long-term potentiation (LTP) in neurons. CaMKs have promiscuous and overlapping substrate recognition ... -
Vinculin-mediated Mechanocoupling in Epithelial Sheet Expansion
(2020)Cell migration and multicellular interactions are essential for the formation and maintenance of tissue structure. The dysregulation of these processes also contributes to developmental defects and pathological processes. ...
