Now showing items 1-7 of 7

    • A population model of folate-mediated one-carbon metabolism. 

      Duncan, Tanya M; Reed, Michael C; Nijhout, H Frederik (Nutrients, 2013-07-05)
      BACKGROUND: Previous mathematical models for hepatic and tissue one-carbon metabolism have been combined and extended to include a blood plasma compartment. We use this model to study how the concentrations of metabolites ...
    • Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. 

      Iskandar, Bermans J; Rizk, Elias; Meier, Brenton; Hariharan, Nithya; Bottiglieri, Teodoro; Finnell, Richard H; Jarrard, David F; ... (15 authors) (J Clin Invest, 2010-05)
      The folate pathway plays a crucial role in the regeneration and repair of the adult CNS after injury. Here, we have shown in rodents that such repair occurs at least in part through DNA methylation. In animals with combined ...
    • High dosage folic acid supplementation, oral cleft recurrence and fetal growth. 

      Wehby, George L; Félix, Têmis Maria; Goco, Norman; Richieri-Costa, Antonio; Chakraborty, Hrishikesh; Souza, Josiane; Pereira, Rui; ... (10 authors) (International journal of environmental research and public health, 2013-02-04)
      <h4>Objectives</h4>To evaluate the effects of folic acid supplementation on isolated oral cleft recurrence and fetal growth.<h4>Patients and methods</h4>The study included 2,508 women who were at-risk for oral cleft recurrence ...
    • Imaging biomarker roadmap for cancer studies. 

      O'Connor, James PB; Aboagye, Eric O; Adams, Judith E; Aerts, Hugo JWL; Barrington, Sally F; Beer, Ambros J; Boellaard, Ronald; ... (77 authors) (Nature reviews. Clinical oncology, 2017-03)
      Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET ...
    • Oral cleft prevention program (OCPP). 

      Wehby, George L; Goco, Norman; Moretti-Ferreira, Danilo; Felix, Temis; Richieri-Costa, Antonio; Padovani, Carla; Queiros, Fernanda; ... (14 authors) (BMC pediatrics, 2012-11-26)
      Oral clefts are one of the most common birth defects with significant medical, psychosocial, and economic ramifications. Oral clefts have a complex etiology with genetic and environmental risk factors. There are suggestive ...
    • Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis. 

      Zhai, Xiangjun; Gao, Jun; Hu, Zhibin; Tang, Jinhai; Qin, Jianwei; Wang, Shui; Wang, Xuechen; ... (14 authors) (BMC cancer, 2006-01)
      BACKGROUND: Accumulative evidence suggests that low folate intake is associated with increased risk of breast cancer. Polymorphisms in genes involved in folate metabolism may influence DNA methylation, nucleotide synthesis, ...
    • Vitamin B12 and Homocysteine Associations with Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging. 

      Vidoni, ML; Pettee Gabriel, K; Luo, ST; Simonsick, EM; Day, RS (The journal of nutrition, health & aging, 2017-01)
      This study aimed to assess the independent associations of serum levels of vitamin B12 and plasma concentrations of homocysteine with gait speed decline.This study utilized longitudinal analysis of participants 50 years ...