Now showing items 1-3 of 3

    • Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. 

      Fong, AM; Lefkowitz, Robert J; Patel, DD; Premont, Richard Thomas; Richardson, RM; Yu, Y-RA (Proc Natl Acad Sci U S A, 2002-05-28)
      Lymphocyte chemotaxis is a complex process by which cells move within tissues and across barriers such as vascular endothelium and is usually stimulated by chemokines such as stromal cell-derived factor-1 (CXCL12) acting ...
    • Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. 

      Diversé-Pierluissi, M; Drazner, Mark H; Dyer, SL; Freedman, NJ; Lefkowitz, Robert J; Oppermann, M; Peppel, Karsten C (Proc Natl Acad Sci U S A, 1996-07-23)
      Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases (GRKs) constitute a family of serine/threonine kinases that play a major role in the agonist-induced phosphorylation and desensitization ...
    • The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment. 

      Caron, MG; Espinoza, S; Gainetdinov, RR; Managò, F; Premont, Richard Thomas; Salahpour, A; Sotnikova, TD (Sci Rep, 2012)
      G protein-coupled Receptor Kinase 6 (GRK6) belongs to a family of kinases that phosphorylate GPCRs. GRK6 levels were found to be altered in Parkinson's Disease (PD) and D(2) dopamine receptors are supersensitive in mice ...