Now showing items 1-8 of 8

    • An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. 

      E, Lezi; Zhou, Ting; Koh, Sehwon; Chuang, Marian; Sharma, Ruchira; Pujol, Nathalie; Chisholm, Andrew D; ... (10 authors) (Neuron, 2018-01-03)
      Infections have been identified as possible risk factors for aging-related neurodegenerative diseases, but it remains unclear whether infection-related immune molecules have a causative role in neurodegeneration during aging. ...
    • Concentration-dependent recruitment of mammalian odorant receptors 

      Hu, Xiaoyang Serene (2019)
      Deciphering natural odor plumes with dynamic changes in odor concentrations presents a common challenge to all animals. A fundamental challenge in studying the organization principles of the olfactory system to encode odor ...
    • Explorations in Olfactory Receptor Structure and Function 

      Ho, Jianghai (2014)
      Olfaction is one of the most primitive of our senses, and the olfactory receptors that mediate this very important chemical sense comprise the largest family of genes in the mammalian genome. It is therefore surprising that ...
    • Functional Selectivity at the Dopamine D2 Receptor 

      Peterson, Sean Michael (2015)
      The neuromodulator dopamine signals through the dopamine D2 receptor (D2R) to modulate central nervous system functions through diverse signal transduction pathways. D2R is a prominent target for drug treatments in disorders ...
    • How Yeast Cells Find Their Mates 

      Henderson, Nicholas Trubiano (2019)
      Extracellular chemical gradients provide signals that guide a broad spectrum of different cellular processes. By accurately sensing and responding to chemical gradients, immune cells can chase down invading pathogens, sperm ...
    • New Insights into GPCR–Transducer Coupling 

      Cahill, Thomas J. (2018)
      β-arrestins (βarrs) interact with G protein-coupled receptors (GPCRs) to desensitize G protein signaling, initiate signaling on their own, and mediate receptor endocytosis.  Using a panel of GPCRs believed to couple differently ...
    • Non-Dopaminergic Motor Control: an Investigation of Serotonergic Circuitry in Parkinson’s Disease 

      Dibble, Michael Ryan Clifford (2018)
      The loss of nigrostriatal dopaminergic neurons is the fundamental hallmark of Parkinson’s disease (PD). In early PD stages, this is ameliorated by dopamine (DA) supplementation; however, as the disease progresses, the complete ...
    • Physiological Functions of Biased Signaling at the Chemokine Receptor CXCR3 

      Smith, Jeffrey (2019)
      G protein-coupled receptors (GPCRs) are the largest class of receptors in the human genome and one of the most common drug targets. It is now well-established that GPCRs can signal through multiple transducers, including ...