Now showing items 1-5 of 5

    • Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom. 

      Bastidas, RJ; Cardenas, Maria E; Heitman, Joseph; Li, W; Shertz, CA (BMC Genomics, 2010-09-23)
      BACKGROUND: The nutrient-sensing Tor pathway governs cell growth and is conserved in nearly all eukaryotic organisms from unicellular yeasts to multicellular organisms, including humans. Tor is the target of the immunosuppressive ...
    • Evolutionary genomics and adaptive evolution of the Hedgehog gene family (Shh, Ihh and Dhh) in vertebrates. 

      Antunes, A; Gilbert, M Thomas P; Jarvis, Erich David; Johnson, WE; O'Brien, Stephen J; Pereira, J; Vasconcelos, V; ... (8 authors) (PLoS One, 2014)
      The Hedgehog (Hh) gene family codes for a class of secreted proteins composed of two active domains that act as signalling molecules during embryo development, namely for the development of the nervous and skeletal systems ...
    • Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. 

      Abrahams, BS; Alvarez Retuerto, AI; Bradfield, JP; Bucan, M; Buxbaum, JD; Cantor, RM; Cook, EH; ... (36 authors) (PLoS Genet, 2009-06)
      The genetics underlying the autism spectrum disorders (ASDs) is complex and remains poorly understood. Previous work has demonstrated an important role for structural variation in a subset of cases, but has lacked the resolution ...
    • The characterization of twenty sequenced human genomes. 

      Campbell, CR; Cirulli Rogers, Elizabeth T; Dickson, SP; Fellay, J; Ge, Dongliang; Goedert, JJ; Goldstein, David Benjamin; ... (25 authors) (PLoS Genet, 2010-09-09)
      We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten "case" genomes from individuals ...
    • The genome of a songbird. 

      Adam, I; Arnold, AP; Backström, N; Balakrishnan, CN; Batzer, MA; Birkhead, T; Blatti, Charles A; ... (82 authors) (Nature, 2010-04-01)
      The zebra finch is an important model organism in several fields with unique relevance to human neuroscience. Like other songbirds, the zebra finch communicates through learned vocalizations, an ability otherwise documented ...