Browsing by Subject "Gene expression"
Now showing items 1-9 of 9
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Carbon and Water Relations in Pinus Taeda: Bridging the Gap across Plant Physiology, Genomics, and Global Climate Change
(2008-06-23)Plants respond to changes in their local environment and, at the same time, influence the environment at a global scale. The molecular and physiological mechanisms regulating this interaction are not completely understood ... -
Factor Models to Describe Linear and Non-linear Structure in High Dimensional Gene Expression Data
(2011)An important problem in the analysis of gene expression data is the identification of groups of features that are coherently expressed. For example, one often wishes to know whether a group of genes, clustered because of ... -
Gene Expression Analysis in Neurons throughout Late-Onset Alzheimer’s Disease Pathological Progression
(2017-05-04)Over 20 susceptibility loci for late-onset Alzheimer’s disease (LOAD) have been identified in large-scale genome-wide association studies (GWAS), and several past studies have found differences in gene expression between ... -
Genetic and Epigenetic Regulation of Starvation Resistance in Caenorhabditis elegans
(2021)Fluctuations in nutrient availability occur for nearly all species, and adaptation to endure starvation conditions is essential. Genetic pathways involved in regulating starvation resistance are implicated in aging and complex ... -
Localized Correlation Analysis and Genetic Association with Cardiovascular Disease
(2010)Variations in gene expression are potential risk factors for atherosclerosis, which is one of the most common forms of cardiovascular disease. We performed a localized Pearson correlation test in 372 individuals from seven ... -
Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability.
(Arthritis Res Ther, 2017-01-23)BACKGROUND: To identify molecular alterations in skeletal muscle in rheumatoid arthritis (RA) that may contribute to ongoing disability in RA. METHODS: Persons with seropositive or erosive RA (n = 51) and control subjects ... -
Transcription Factor-Centric Approaches to Identify Regulatory Driver Mutations in Cancer
(2020)Most previous efforts to identify cancer driver mutations have focused on protein-coding genes. In recent years, the decreasing costs of DNA sequencing have enabled whole-genome sequencing (WGS) studies of thousands of tumor ... -
Using Single-Cell Analyses to Uncover Transcriptional Heterogeneity in Plasmodium falciparum
(2018)Malaria persists as a global health problem, with 212 million cases and 429,000 deaths worldwide in 2015 alone. It is caused by the apicomplexan parasite Plasmodium, which follows a complex life cycle that consists of multiple ... -
Validation of a host response test to distinguish bacterial and viral respiratory infection.
(EBioMedicine, 2019-10-17)BACKGROUND:Distinguishing bacterial and viral respiratory infections is challenging. Novel diagnostics based on differential host gene expression patterns are promising but have not been translated to a clinical platform ...
