Now showing items 1-11 of 11

    • Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. 

      Adachi, J; Aizawa, K; Arakawa, T; Baldarelli, R; Batalov, S; Beisel, KW; Birney, E; ... (139 authors) (Nature, 2002-12-05)
      Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA transcripts from the mouse, and to ensure ...
    • Analysis of the mouse transcriptome for genes involved in the function of the nervous system. 

      Batalov, S; Beisel, KW; Bono, H; Carninci, P; Fletcher, CF; Grimmond, S; GSL Members; ... (22 authors) (Genome Res, 2003-06)
      We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including ...
    • apex: phylogenetics with multiple genes. 

      Archer, F; Goudet, J; Harris, R; Jombart, T; Kamvar, Z; Lapp, Hilmar; Paradis, E; ... (8 authors) (Mol Ecol Resour, 2017-01)
      Genetic sequences of multiple genes are becoming increasingly common for a wide range of organisms including viruses, bacteria and eukaryotes. While such data may sometimes be treated as a single locus, in practice, a number ...
    • cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure. 

      Bolanowski, MA; Bouvier, M; Caron, MG; Collins, Sheila; Lefkowitz, Robert J (Proc Natl Acad Sci U S A, 1989-07)
      In addition to conveying cellular responses to an effector molecule, receptors are often themselves regulated by their effectors. We have demonstrated that epinephrine modulates both the rate of transcription of the beta ...
    • Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. 

      Caron, MG; Kobilka, BK; Kobilka, TS; Lefkowitz, Robert J; Regan, JW; Yang-Feng, TL (Proc Natl Acad Sci U S A, 1988-09)
      An alpha 2-adrenergic receptor subtype has been cloned from a human kidney cDNA library using the gene for the human platelet alpha 2-adrenergic receptor as a probe. The deduced amino acid sequence resembles the human platelet ...
    • Comparative genomics reveals insights into avian genome evolution and adaptation. 

      Alfaro-Núñez, A; Alström, P; An, N; Antunes, A; Avian Genome Consortium; Bertelsen, MF; Borges, R; ... (106 authors) (Science, 2014-12-12)
      Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. ...
    • Gene expression signatures that predict radiation exposure in mice and humans. 

      Chao, Nelson J; Chute, JP; Dressman, HK; Ginsburg, Geoffrey Steven; Marshall, D; Meadows, Sarah K; Muramoto, Garrett G; ... (8 authors) (PLoS Med, 2007-04)
      BACKGROUND: The capacity to assess environmental inputs to biological phenotypes is limited by methods that can accurately and quantitatively measure these contributions. One such example can be seen in the context of exposure ...
    • Molecules to Mind: the Construction of Emotion 

      Perlman, Susan Beth (2009)
      In recent years, there has been increasing scientific interest in the biological basis of emotion. By characterizing the neural and genetic basis of affective functioning, new research has the potential to contribute to ...
    • Recursive directional ligation by plasmid reconstruction allows rapid and seamless cloning of oligomeric genes. 

      McDaniel, JR; Mackay, JA; Quiroz, FG; Chilkoti, A (Biomacromolecules, 2010-04-12)
      This paper reports a new strategy, recursive directional ligation by plasmid reconstruction (PRe-RDL), to rapidly clone highly repetitive polypeptides of any sequence and specified length over a large range of molecular ...
    • Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity. 

      Haskins, KA; Russell, JF; Gaddis, N; Dressman, HK; Aballay, A (Dev Cell, 2008-07)
      The endoplasmic reticulum stress response, also known as the unfolded protein response (UPR), has been implicated in the normal physiology of immune defense and in several disorders, including diabetes, cancer, ...
    • Whole-genome analyses resolve early branches in the tree of life of modern birds. 

      Aberer, AJ; Alfaro-Núñez, A; Alström, P; Bailey, T; Barker, FK; Bayzid, MS; Bertelsen, MF; ... (105 authors) (Science, 2014-12-12)
      To better determine the history of modern birds, we performed a genome-scale phylogenetic analysis of 48 species representing all orders of Neoaves using phylogenomic methods created to handle genome-scale data. We recovered ...